Mepyramine maleate | Tocris Bioscience 0660 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Mepyramine maleate

catalog :

0660

quantity :

100 mg

price :

83 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Littmann T, Ozawa T, Hoffmann C, Buschauer A, Bernhardt G. A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells. Sci Rep. 2018;8:17179 pubmed publisher
Kurtz K, Moor A, Souza Smith F, Breslin J. Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics. Microcirculation. 2014;21:593-605 pubmed publisher
Connelly W, Shenton F, Lethbridge N, Leurs R, Waldvogel H, Faull R, et al. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol. 2009;157:55-63 pubmed publisher
Flamand N, Plante H, Picard S, Laviolette M, Borgeat P. Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol. 2004;141:552-61 pubmed
Brandt E, Strait R, Hershko D, Wang Q, Muntel E, Scribner T, et al. Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest. 2003;112:1666-77 pubmed

product information

brand :

Tocris

master code :

0660

SKU :

0660/100

product name :

Mepyramine maleate

description :

Selective H1 inverse agonist

target :

Histamine H1 Inverse Agonists

category :

Small Molecules

unit size :

100 mg

observed molecular weight :

401.46

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inverse agonist for the H1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters Gq/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

catalog number base :

660

product keywords :

Selective H1 inverse agonists Receptors Histamine histaminergic Pyrilamine maleate Histamine H1 Receptors 0660,

extended description :

Selective H1 inverse agonist

chemical name text :

2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate

formula :

C 17 H 23 N 3 O.C 4 H 4 O 4

formula text :

C17H23N3O.C4H4O4

cas num :

59-33-6

2020 USD :

2021 USD :

83 USD

alt names :

Pyrilamine maleate

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage