0654/1G | Tocris Bioscience 0654/1G product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0654/1G

catalog :

0654/1G

quantity :

1 g

price :

133 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
McKeithan W, Savchenko A, YU M, Cerignoli F, Bruyneel A, Price J, et al. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017;8:766 pubmed publisher
Florea A, Varghese E, McCallum J, Mahgoub S, Helmy I, Varghese S, et al. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget. 2017;8:22876-22893 pubmed publisher
Ferland D, Darios E, Neubig R, Sjögren B, Truong N, Torres R, et al. Chemerin-induced arterial contraction is Gi- and calcium-dependent. Vascul Pharmacol. 2017;88:30-41 pubmed publisher
BraganÃ§a B, Oliveira Monteiro N, Ferreirinha F, Lima P, Faria M, Fontes Sousa A, et al. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol. 2016;7:45 pubmed publisher
Azab W, Gramatica A, Herrmann A, Osterrieder N. Binding of alphaherpesvirus glycoprotein H to surface Î±4Î²1-integrins activates calcium-signaling pathways and induces phosphatidylserine exposure on the plasma membrane. MBio. 2015;6:e01552-15 pubmed publisher
Fransen P, Van Hove C, Leloup A, Martinet W, De Meyer G, Lemmens K, et al. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. PLoS ONE. 2015;10:e0121634 pubmed publisher
Dhillon S, Dóró E, Magyary I, Egginton S, Sik A, Muller F. Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs. PLoS ONE. 2013;8:e60552 pubmed publisher
Chang M, Lin L, Wu H, Ho Y, Hsien H, Wang T, et al. Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. Carcinogenesis. 2013;34:1096-104 pubmed publisher
Xia M, Shahane S, Huang R, Titus S, Shum E, Zhao Y, et al. Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol. 2011;252:250-8 pubmed publisher
Szikra T, Barabas P, Bartoletti T, Huang W, Akopian A, Thoreson W, et al. Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS ONE. 2009;4:e6723 pubmed publisher
Wieland H, Hechtel N, Faigle M, Neumeister B. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. FEMS Immunol Med Microbiol. 2006;47:296-301 pubmed

product information

master code :

654

SKU :

0654/1G

product name :

Verapamil hydrochloride

unit size :

1 g

description :

CaV1.x blocker

target :

Cav1.x Channel Blockers

category :

Small Molecules

purity :

99%

observed molecular weight :

491.07

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Verapamil hydrochloride is an L-type calcium channel blocker, anti-arrythmic, vasodilator and adrenergic antagonist. Induces autophagy by modulating cellular metabolism. Verapamil is a P-glycoprotein inhibitor and can reverse resistance to glucocorticoids and cancer treatments. Verapamil has been identified as targeting human host proteins that interact with SARS-CoV-2.

top caption :

Pluripotent stem cell-derived cardiomyocytes secrete Pro-BNP in response to small molecule-induction of cardiac hypertrophy.

extended description :

CaV1.x blocker

chemical name text :

-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy- -(1-methylethyl)benzeneacetonitrile hydrochloride

formula :

C27H38N2O4.HCl

formula text :

C27H38N2O4.HCl

cas num :

152-11-4

USD :

133 USD

product details :

CaV1.x blocker

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage