0652/100 | Tocris Bioscience 0652/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0652/100

catalog :

0652/100

quantity :

100 mg

price :

111 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Jain J, Jain S, Walker L, Tekwani B. Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. BMC Pharmacol Toxicol. 2017;18:40 pubmed publisher
Del Prete D, Rice R, Rajadhyaksha A, D ADAMIO L. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. J Biol Chem. 2016;291:17209-27 pubmed publisher
Helmy M, Helmy M, El Mas M. Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs. PLoS ONE. 2015;10:e0142303 pubmed publisher
Girgis E, Mahoney J, Khalil R, SOLIMAN M. Effect of thalidomide and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line. Oncol Lett. 2010;1:663-667 pubmed
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Gu X, Zheng Y, Ren B, Zhang R, Mei F, Zhang J, et al. Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-? expression in a mouse model. Mol Pain. 2010;6:64 pubmed publisher
Sandur S, Pandey M, Sung B, Aggarwal B. 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. Mol Cancer Res. 2010;8:107-18 pubmed publisher
Pandey M, Sung B, Aggarwal B. Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. Int J Cancer. 2010;127:282-92 pubmed publisher
Sung B, Kunnumakkara A, Sethi G, Anand P, Guha S, Aggarwal B. Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Mol Cancer Ther. 2009;8:959-70 pubmed publisher
Pathak A, Bhutani M, Nair A, Ahn K, Chakraborty A, Kadara H, et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res. 2007;5:943-55 pubmed
Ahn K, Sethi G, Chao T, Neuteboom S, Chaturvedi M, Palladino M, et al. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood. 2007;110:2286-95 pubmed
Rocha A, Fernandes E, Quintão N, Campos M, Calixto J. Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw. Br J Pharmacol. 2006;148:688-95 pubmed
Eter N, Spitznas M. DMSO mimics inhibitory effect of thalidomide on choriocapillary endothelial cell proliferation in culture. Br J Ophthalmol. 2002;86:1303-5 pubmed

product information

master code :

652

SKU :

0652/100

product name :

Thalidomide

unit size :

100 mg

description :

Binds cereblon; also TNF- synthesis inhibitor

target :

Cytokine Compounds

category :

Small Molecules

purity :

99%

observed molecular weight :

258.23

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Thalidomide is a selective inhibitor of tumor necrosis factor (TNF- ) synthesis. Anti-inflammatory; promotes T-cell activation. Predicted to reduce cytokine release in SARS-CoV-2 infection. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogenic and sedative-hypnotic. Promotes degradation of transcription factor SALL4.

top caption :

Binds cereblon; also TNF- synthesis inhibitor

extended description :

Binds cereblon; also TNF- synthesis inhibitor

chemical name text :

N-(2,6-dioxo-3-piperidinyl)phthalimide

formula :

C13H10N2O4

formula text :

C13H10N2O4

cas num :

50-35-1

USD :

111 USD

product details :

Binds cereblon; also TNF- synthesis inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage