Thioperamide | Tocris Bioscience 0644 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Thioperamide

catalog :

0644

quantity :

10 mg (also 50 mg)

price :

123 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Francis H, Demorrow S, Venter J, Onori P, White M, Gaudio E, et al. Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma. Gut. 2012;61:753-64 pubmed publisher
Holden N, Gong W, King E, Kaur M, Giembycz M, Newton R. Potentiation of NF-kappaB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Br J Pharmacol. 2007;152:891-902 pubmed
Takahashi K, Suwa H, Ishikawa T, Kotani H. Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype. J Clin Invest. 2002;110:1791-9 pubmed
Robinson A, Dickenson J. Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine H(1) receptor in DDT(1)MF-2 cells. Br J Pharmacol. 2001;133:1378-86 pubmed

product information

brand :

Tocris

master code :

0644

SKU :

0644/10

product name :

Thioperamide

description :

H3 antagonist; also H4 inverse agonist

target :

Histamine H3 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

292.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent histamine H3 and H4 antagonist/inverse agonist. Ki values are 25 and 27 nM for human recombinant H3 and H4 receptors respectively. Blocks eosinophil shape change (IC50 = 1.4 u M) and chemotaxis (IC50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier.

catalog number base :

644

product keywords :

H4 inverse agonists H3 antagonists Receptors Histamine histaminergic Histamine H3 Receptors Histamine H4 Receptors 0644,

extended description :

H3 antagonist; also H4 inverse agonist

chemical name text :

N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide

formula :

C 15 H 24 N 4 S

formula text :

C15H24N4S

cas num :

106243-16-7

2020 USD :

119

2021 USD :

123 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage