0644/10 | Tocris Bioscience 0644/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0644/10

catalog :

0644/10

quantity :

10 mg (also 50 mg)

price :

156 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Francis H, Demorrow S, Venter J, Onori P, White M, Gaudio E, et al. Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma. Gut. 2012;61:753-64 pubmed publisher
Holden N, Gong W, King E, Kaur M, Giembycz M, Newton R. Potentiation of NF-kappaB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Br J Pharmacol. 2007;152:891-902 pubmed
Takahashi K, Suwa H, Ishikawa T, Kotani H. Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype. J Clin Invest. 2002;110:1791-9 pubmed
Robinson A, Dickenson J. Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine H(1) receptor in DDT(1)MF-2 cells. Br J Pharmacol. 2001;133:1378-86 pubmed

product information

master code :

644

SKU :

0644/10

product name :

Thioperamide

unit size :

10 mg (also 50 mg)

description :

H3 antagonist; also H4 inverse agonist

target :

Histamine H3 Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

292.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Thioperamide is a potent histamine H3 and H4 antagonist/inverse agonist. Ki values are 25 and 27 nM for human recombinant H3 and H4 receptors respectively. Blocks eosinophil shape change (IC50 = 1.4 u M) and chemotaxis (IC50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier.

top caption :

H3 antagonist; also H4 inverse agonist

extended description :

H3 antagonist; also H4 inverse agonist

chemical name text :

N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide

formula :

C15H24N4S

formula text :

C15H24N4S

cas num :

106243-16-7

USD :

156 USD

product details :

H3 antagonist; also H4 inverse agonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage