0625/10 | Tocris Bioscience 0625/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0625/10

catalog :

0625/10

quantity :

10 mg (also 50 mg)

price :

100 USD

more info or order :

Tocris Bioscience product webpage

citations: 22

Reference
McEwan T, Sophocleous R, Cuthbertson P, Mansfield K, Sanderson Smith M, Sluyter R. Autocrine regulation of wound healing by ATP release and P2Y2 receptor activation. Life Sci. 2021;283:119850 pubmed publisher
Cuthbertson P, Geraghty N, Adhikary S, Casolin S, Watson D, Sluyter R. P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model. Clin Sci (Lond). 2021;135:495-513 pubmed publisher
Cruz A, Beall C. Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance. Front Physiol. 2020;11:567378 pubmed publisher
Coddou C, Sandoval R, Hevia M, Stojilkovic S. Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor. Neurosci Lett. 2019;690:219-224 pubmed publisher
Conley J, Radhakrishnan S, Valentino S, Tantama M. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor. PLoS ONE. 2017;12:e0187481 pubmed publisher
Yamashita T, Yamamoto S, Zhang J, Kometani M, Tomiyama D, Kohno K, et al. Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury. PLoS ONE. 2016;11:e0165189 pubmed publisher
Zhang P, Zhang G, Zhou W, Weng S, Yang X, Zhong Y. Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells. Sci Rep. 2016;6:28938 pubmed publisher
Pozner A, Xu B, Palumbos S, Gee J, Tvrdik P, Capecchi M. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse. Front Mol Neurosci. 2015;8:12 pubmed publisher
Cheung K, Marques da Silva C, Vairo L, dos Santos D, Goldenberg R, Coutinho Silva R, et al. Pharmacological and molecular characterization of functional P2 receptors in rat embryonic cardiomyocytes. Purinergic Signal. 2015;11:127-38 pubmed publisher
Fonseca B, MartÃnez Ãguila A, DÃaz HernÃ¡ndez M, Pintor J. Diadenosine tetraphosphate contributes to carbachol-induced tear secretion. Purinergic Signal. 2015;11:87-93 pubmed publisher
Bulavina L, Szulzewsky F, Rocha A, Krabbe G, Robson S, Matyash V, et al. NTPDase1 activity attenuates microglial phagocytosis. Purinergic Signal. 2013;9:199-205 pubmed publisher
Ievglevskyi O, Palygin O, Kondratskaya E, Grebenyuk S, Krishtal O. Modulation of ATP-induced LTP by cannabinoid receptors in rat hippocampus. Purinergic Signal. 2012;8:705-13 pubmed publisher
Mungenast A. Diacylglycerol signaling underlies astrocytic ATP release. Neural Plast. 2011;2011:537659 pubmed publisher
Rodríguez Zayas A, Torrado A, Rosas O, Santiago J, Figueroa J, Miranda J. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. J Mol Neurosci. 2012;46:167-76 pubmed publisher
Kouzaki H, Iijima K, Kobayashi T, O Grady S, Kita H. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol. 2011;186:4375-87 pubmed publisher
Thrane A, Rappold P, Fujita T, Torres A, Bekar L, Takano T, et al. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A. 2011;108:846-51 pubmed publisher
Gomez Gonzalo M, Losi G, Chiavegato A, Zonta M, Cammarota M, Brondi M, et al. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol. 2010;8:e1000352 pubmed publisher
Takata N, Hirase H. Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo. PLoS ONE. 2008;3:e2525 pubmed publisher
Kennedy C, Tasker P, Gallacher G, Westfall T. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci. 2007;27:845-51 pubmed
Zhong Y, Dunn P, Burnstock G. Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties. Br J Pharmacol. 2001;132:221-33 pubmed
Liu M, Dunn P, King B, Burnstock G. Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology. Br J Pharmacol. 1999;128:61-8 pubmed
Gao J, Zhao J, Rayner S, Van Helden D. Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2. Br J Pharmacol. 1999;127:1597-602 pubmed

product information

master code :

625

SKU :

0625/10

product name :

PPADS tetrasodium salt

unit size :

10 mg (also 50 mg)

description :

Non-selective P2 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

observed molecular weight :

599.3

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PPADS tetrasodium salt is a non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 u M), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. PPADS tetrasodium salt delays onset of calcium responses to mild hypoosmotic stress in cortical slices. PPADS tetrasodium salt blocks P2X7 and reduces clinical and histological graft-versus-host disease development in a humanised mouse model. . 2 5 -isomer also available.

top caption :

Non-selective P2 antagonist

extended description :

Non-selective P2 antagonist

chemical name text :

Pyridoxalphosphate-6-azophenyl-2 ,4 -disulfonic acid tetrasodium salt

formula :

C14H10N3Na4O12PS2

formula text :

C14H10N3Na4O12PS2

cas num :

192575-19-2

USD :

100 USD

product details :

Non-selective P2 antagonist

storage :

Desiccate at -20░C

more info or order :

Tocris Bioscience product webpage