product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Prazosin hydrochloride
catalog :
0623
quantity :
100 mg
price :
108 USD
more info or order :
citations: 12
Reference
Assad Kahn S, Costa S, Gholamin S, Nitta R, Dubois L, Fève M, et al. The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med. 2016;8:511-26 pubmed publisher
Delaney A, Crane J. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep. 2016;6:19255 pubmed publisher
Skelly M, Weiner J. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav. 2014;4:468-83 pubmed publisher
Corcoran A, Commons K, Wu Y, Smith J, Harris M, Richerson G. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. J Neurosci. 2014;34:51-9 pubmed publisher
Hughes S, Hickey L, Hulse R, Lumb B, Pickering A. Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. Pain. 2013;154:1680-90 pubmed publisher
Zemkova H, Stojilkovic S, Klein D. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology. 2011;152:3842-51 pubmed publisher
Tjen A Looi S, Hsiao A, Longhurst J. Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats. Am J Physiol Heart Circ Physiol. 2011;300:H1003-12 pubmed publisher
Ajmo C, Collier L, Leonardo C, Hall A, Green S, Womble T, et al. Blockade of adrenoreceptors inhibits the splenic response to stroke. Exp Neurol. 2009;218:47-55 pubmed publisher
Huang C, Liang Y, Lee C, Wu M, Hsu K. Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology. 2009;34:1979-92 pubmed publisher
Zhu Z, Munhall A, Johnson S. Tyramine excites rat subthalamic neurons in vitro by a dopamine-dependent mechanism. Neuropharmacology. 2007;52:1169-78 pubmed
Moura E, Afonso J, Hein L, Vieira Coelho M. Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol. 2006;149:1049-58 pubmed
Sjöblom M, Jedstedt G, Flemstrom G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest. 2001;108:625-33 pubmed
product information
brand :
Tocris
master code :
0623
SKU :
0623/100
product name :
Prazosin hydrochloride
description :
1 and 2B antagonist; also MT3 antagonist
target :
Adrenergic alpha-1 Receptor Antagonists
category :
Small Molecules
unit size :
100 mg
purity :
99%
observed molecular weight :
419.87
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
1 and 2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM).
catalog number base :
623
product keywords :
1-adrenoceptor alpha1-adrenoceptor a1-adrenoceptor antagonists MT3 1-adrenergic alpha1-adrenergic a1-adrenergic Receptors MT Melatonin Adrenergic Alpha-1 Receptors Melatonin (MT) Receptors Adrenergic Alpha-2 Receptors 0623,
extended description :
1 and 2B antagonist; also MT3 antagonist
chemical name text :
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
formula :
C 19 H 21 N 5 O 4 .HCl
formula text :
C19H21N5O4.HCl
cas num :
19237-84-4
2020 USD :
103
2021 USD :
108 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK