0623/100 | Tocris Bioscience 0623/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0623/100

catalog :

0623/100

quantity :

100 mg

price :

140 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Roewe J, Higer M, Riehl D, Gericke A, Radsak M, Bosmann M. Neuroendocrine Modulation of IL-27 in Macrophages. J Immunol. 2017;199:2503-2514 pubmed publisher
Assad Kahn S, Costa S, Gholamin S, Nitta R, Dubois L, FÃ¨ve M, et al. The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCÎ´-dependent inhibition of the AKT pathway. EMBO Mol Med. 2016;8:511-26 pubmed publisher
Delaney A, Crane J. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep. 2016;6:19255 pubmed publisher
Skelly M, Weiner J. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav. 2014;4:468-83 pubmed publisher
Ho J, Anekonda V, Thompson B, Zhu M, Curry R, Hwang B, et al. Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology. 2014;155:2845-57 pubmed publisher
Corcoran A, Commons K, Wu Y, Smith J, Harris M, Richerson G. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. J Neurosci. 2014;34:51-9 pubmed publisher
Hughes S, Hickey L, Hulse R, Lumb B, Pickering A. Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. Pain. 2013;154:1680-90 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Zemkova H, Stojilkovic S, Klein D. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology. 2011;152:3842-51 pubmed publisher
Tjen A Looi S, Hsiao A, Longhurst J. Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats. Am J Physiol Heart Circ Physiol. 2011;300:H1003-12 pubmed publisher
Ajmo C, Collier L, Leonardo C, Hall A, Green S, Womble T, et al. Blockade of adrenoreceptors inhibits the splenic response to stroke. Exp Neurol. 2009;218:47-55 pubmed publisher
Huang C, Liang Y, Lee C, Wu M, Hsu K. Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology. 2009;34:1979-92 pubmed publisher
Zhu Z, Munhall A, Johnson S. Tyramine excites rat subthalamic neurons in vitro by a dopamine-dependent mechanism. Neuropharmacology. 2007;52:1169-78 pubmed
Moura E, Afonso J, Hein L, Vieira Coelho M. Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol. 2006;149:1049-58 pubmed
Sjöblom M, Jedstedt G, Flemstrom G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest. 2001;108:625-33 pubmed

product information

master code :

623

SKU :

0623/100

product name :

Prazosin hydrochloride

unit size :

100 mg

description :

1 and 2B antagonist; also MT3 antagonist

target :

Adrenergic alpha-1 Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

419.87

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Prazosin hydrochloride is an 1 and 2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). In prostate cancer cells, Prazosin induces DNA damage stress, Cdk1 inactivation, G2 checkpoint arrest and apoptosis. In mice bearing prostate cancer xenografts, oral administration of Prazosin reduces tumor mass.

top caption :

1 and 2B antagonist; also MT3 antagonist

extended description :

1 and 2B antagonist; also MT3 antagonist

chemical name text :

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

formula :

C19H21N5O4.HCl

formula text :

C19H21N5O4.HCl

cas num :

19237-84-4

USD :

140 USD

product details :

1 and 2B antagonist; also MT3 antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage