product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
0600/100
catalog :
0600/100
quantity :
100 mg
price :
150 USD
more info or order :
citations: 32
Reference
Korte N, Barkaway A, Wells J, Freitas F, Sethi H, Andrews S, et al. Inhibiting Ca2+ channels in Alzheimer's disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia. Nat Neurosci. 2024;27:2086-2100 pubmed publisher
O Malley J, Seibt F, Chin J, Beierlein M. TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations. J Neurosci. 2020;40:4813-4823 pubmed publisher
Doshina A, Gourgue F, Onizuka M, Opsomer R, Wang P, Ando K, et al. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission. Sci Rep. 2017;7:370 pubmed publisher
Bellono N, Leitch D, Julius D. Molecular basis of ancestral vertebrate electroreception. Nature. 2017;543:391-396 pubmed publisher
Robinson S, Lee T, Christie D, Birch N. Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons. Front Cell Neurosci. 2015;9:404 pubmed publisher
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes D, Anane D, et al. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1. Nat Commun. 2015;6:8302 pubmed publisher
Dilger E, Krahe T, Morhardt D, Seabrook T, Shin H, Guido W. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci. 2015;35:3652-62 pubmed publisher
Pourbadie H, Naderi N, Mehranfard N, Janahmadi M, Khodagholi F, Motamedi F. Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology. PLoS ONE. 2015;10:e0117555 pubmed publisher
Gan K, Silverman M. Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neurons. Mol Biol Cell. 2015;26:1058-71 pubmed publisher
Schöbel N, Radtke D, Kyereme J, Wollmann N, Cichy A, Obst K, et al. Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem Senses. 2014;39:471-87 pubmed publisher
Clemens A, Johnston D. Age- and location-dependent differences in store depletion-induced h-channel plasticity in hippocampal pyramidal neurons. J Neurophysiol. 2014;111:1369-82 pubmed publisher
Kang S, Liu M, Shi T, Zhao M, Kaang B, Zhuo M. N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice. Mol Pain. 2013;9:58 pubmed publisher
Diekman C, Belle M, Irwin R, Allen C, Piggins H, Forger D. Causes and consequences of hyperexcitation in central clock neurons. PLoS Comput Biol. 2013;9:e1003196 pubmed publisher
Elmer B, Estes M, Barrow S, McAllister A. MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease. J Neurosci. 2013;33:13791-804 pubmed publisher
Siddoway B, Altimimi H, Hou H, Petralia R, Xu B, Stellwagen D, et al. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci. 2013;33:11206-11 pubmed publisher
Liu M, Kang S, Shi T, Koga K, Zhang M, Collingridge G, et al. Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings. J Neurophysiol. 2013;110:505-21 pubmed publisher
Schöbel N, Radtke D, Lübbert M, Gisselmann G, Lehmann R, Cichy A, et al. Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. PLoS ONE. 2012;7:e48005 pubmed publisher
Colgan L, Cavolo S, Commons K, Levitan E. Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites. J Neurosci. 2012;32:15737-46 pubmed publisher
Jurgens C, Bell K, McQuiston A, Guido W. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS ONE. 2012;7:e45717 pubmed publisher
Hulme S, Jones O, Ireland D, Abraham W. Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus. J Neurosci. 2012;32:6785-94 pubmed publisher
Saliba R, Kretschmannova K, Moss S. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. EMBO J. 2012;31:2937-51 pubmed publisher
Shulga A, Magalhães A, Autio H, Plantman S, Di Lieto A, Nykjær A, et al. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci. 2012;32:1757-70 pubmed publisher
Dilger E, Shin H, Guido W. Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse. J Physiol. 2011;589:919-37 pubmed publisher
Higley M, Sabatini B. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci. 2010;13:958-66 pubmed publisher
Murray K, Nakae A, Stephens M, Rank M, D Amico J, Harvey P, et al. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med. 2010;16:694-700 pubmed publisher
Grey K, Burrell B. Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases. J Neurophysiol. 2010;103:2737-46 pubmed publisher
Wu W, Chan C, Surmeier D, Disterhoft J. Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity. J Neurophysiol. 2008;100:1897-908 pubmed publisher
Haeberle H, Bryan L, Vadakkan T, Dickinson M, Lumpkin E. Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells. PLoS ONE. 2008;3:e1750 pubmed publisher
McElligott Z, Winder D. Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders. Neuropsychopharmacology. 2008;33:2313-23 pubmed
Bender V, Bender K, Brasier D, Feldman D. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. J Neurosci. 2006;26:4166-77 pubmed
Facchinetti F, Fasolato C, Del Giudice E, Burgo A, Furegato S, Fusco M, et al. Nimodipine selectively stimulates beta-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage. Neurobiol Aging. 2006;27:218-27 pubmed
Haeberle H, Fujiwara M, Chuang J, Medina M, Panditrao M, Bechstedt S, et al. Molecular profiling reveals synaptic release machinery in Merkel cells. Proc Natl Acad Sci U S A. 2004;101:14503-8 pubmed
product information
master code :
600
SKU :
0600/100
product name :
Nimodipine
unit size :
100 mg
description :
CaV1.x blocker
target :
Cav1.x Channel Blockers
category :
Small Molecules
purity :
99%
observed molecular weight :
418.45
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Nimodipine is a L-type Ca2+ channel blocker. Induces autophagy. Nimodipine is modulating pericytes and other inflammation signals like Hypoxia and leukocyte stalling to improve cognitive function in Alzheimer?s disease. Nimodipine reduces pericytes and other inflammation signals like hypoxia and leukocyte stalling and improves cognitive function in Alzheimer's disease model mice.
top caption :
CaV1.x blocker
extended description :
CaV1.x blocker
chemical name text :
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester
formula :
C21H26N2O7
formula text :
C21H26N2O7
cas num :
66085-59-4
USD :
150 USD
product details :
CaV1.x blocker
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK