product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0593/50
catalog :
0593/50
quantity :
50 mg
price :
251 USD
more info or order :
citations: 11
Reference
Rastogi S, Ellinwood S, Augenstreich J, Mayer Barber K, Briken V. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF. PLoS Pathog. 2021;17:e1009712 pubmed publisher
Morethson P. Extracellular fluid flow and chloride content modulate H(+) transport by osteoclasts. BMC Cell Biol. 2015;16:20 pubmed publisher
Harper M, Poole A. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. Cell Death Dis. 2013;4:e969 pubmed publisher
Grant J, Tran V, Bhattacharya S, Bianchi L. Ionic currents of human trabecular meshwork cells from control and glaucoma subjects. J Membr Biol. 2013;246:167-75 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Sun X, Wang X, Wang G, Xia Y, Liu S, Qu M, et al. Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine. Dig Dis Sci. 2011;56:330-8 pubmed publisher
Sagheddu C, Boccaccio A, Dibattista M, Montani G, Tirindelli R, Menini A. Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells. J Physiol. 2010;588:4189-204 pubmed publisher
Fei G, Wang Y, Liu S, Hu H, Wang G, Qu M, et al. Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol. 2009;296:G823-32 pubmed publisher
Silverman W, Locovei S, Dahl G. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008;295:C761-7 pubmed publisher
Fioretti B, Pietrangelo T, Catacuzzeno L, Franciolini F. Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis. Am J Physiol Cell Physiol. 2005;289:C89-96 pubmed
Li Q, Dong C, Deng A, Katsumata M, Nakadai A, Kawada T, et al. Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother. 2005;49:388-97 pubmed
product information
master code :
593
SKU :
0593/50
product name :
NPPB
unit size :
50 mg
description :
Inhibits calcium-sensitive chloride currents
target :
Calcium-activated Chloride Channel Blockers
category :
Small Molecules
purity :
99%
observed molecular weight :
300.31
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Inhibits calcium-sensitive chloride currents (10 M). Putative GPR35 agonist.
top caption :
Inhibits calcium-sensitive chloride currents
extended description :
Inhibits calcium-sensitive chloride currents
chemical name text :
5-Nitro-2-(3-phenylpropylamino)benzoic acid
formula :
C16H16N2O4
formula text :
C16H16N2O4
cas num :
107254-86-4
USD :
251 USD
product details :
Inhibits calcium-sensitive chloride currents
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK