PCA 4248 | Tocris Bioscience 0571/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PCA 4248

catalog :

0571/10

quantity :

10 mg (also 50 mg)

price :

146 USD

citations: 4

Reference
Hergott C, Roche A, Naidu N, Mesaros C, Blair I, Weiser J. Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. J Clin Invest. 2015;125:3878-90 pubmed publisher
Bachi A, Dos Santos L, Nonogaki S, Jancar S, Jasiulionis M. Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. Mediators Inflamm. 2012;2012:610371 pubmed publisher
Garcia C, Russo R, Guabiraba R, Fagundes C, Polidoro R, Tavares L, et al. Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. PLoS Pathog. 2010;6:e1001171 pubmed publisher
Mathison R, Ho W, Pittman Q, Davison J, Sharkey K. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol. 2004;142:1247-54 pubmed

product information

brand :

Tocris

master code :

571

SKU :

0571/10

product name :

PCA 4248

description :

PAF receptor antagonist

target :

Platelet-activating Factor Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

95%

observed molecular weight :

361.46

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PCA 4248 is a specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC50 value of 1.05 u M and has no significant activity on Ca2+ channels. Active in vivo , antagonizing PAF-induced systemic hypotension and protein-plasma extravasation in rats.

catalog number base :

571

extended description :

PAF receptor antagonist

chemical name text :

1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid methyl 2-(phenylthio)ethyl ester

formula :

C 19 H 23 NO 4 S

formula text :

C19H23NO4S

cas num :

123875-01-4

USD 2021 :

142

USD 2022 :

146 USD

product details :

PAF receptor antagonist

storage :

Desiccate at -20°C