(R)-(-)-alpha-Methylhistamine dihydrobromide | Tocris Bioscience 0569 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(R)-(-)-alpha-Methylhistamine dihydrobromide

catalog :

0569

quantity :

10 mg (also 50 mg)

price :

145 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Rapanelli M, Frick L, Horn K, Schwarcz R, Pogorelov V, Nairn A, et al. The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons. J Biol Chem. 2016;291:21042-21052 pubmed
Spaethling J, Piel D, Dueck H, Buckley P, Morris J, Fisher S, et al. Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. FASEB J. 2014;28:771-80 pubmed publisher
Kim B, Kwon Y, Kim E, So I. Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol. 2013;17:149-56 pubmed publisher
Holden N, Gong W, King E, Kaur M, Giembycz M, Newton R. Potentiation of NF-kappaB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Br J Pharmacol. 2007;152:891-902 pubmed

product information

brand :

Tocris

master code :

0569

SKU :

0569/10

product name :

(R)-(-)-alpha-Methylhistamine dihydrobromide

description :

Potent, standard H3 agonist

target :

Histamine H3 Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

287

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Very potent, high affinity H3 agonist (KD = 50.3 nM) that displays 200-fold selectivity over H4 receptors. Inhibits H3-mediated histamine synthesis and release in the CNS and stimulates H4-mediated eosinophil shape change (EC50 = 66 nM). . S-enantiomer also available.

catalog number base :

569

product keywords :

Potent H3 agonists Receptors Histamine histaminergic (R)-(-)-alpha-Methylhistamine dihydrobromide Histamine H3 Receptors 0569,

extended description :

Potent, standard H3 agonist

chemical name text :

(R)-(-)- -Methyl-1H-imidazole-4-ethanamine dihydrobromide

formula :

C 6 H 11 N 3 .2HBr

formula text :

C6H11N3.2HBr

cas num :

868698-49-1

2020 USD :

142

2021 USD :

145 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage