0569/10 | Tocris Bioscience 0569/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0569/10

catalog :

0569/10

quantity :

10 mg (also 50 mg)

price :

186 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Rapanelli M, Frick L, Horn K, Schwarcz R, Pogorelov V, Nairn A, et al. The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons. J Biol Chem. 2016;291:21042-21052 pubmed
Spaethling J, Piel D, Dueck H, Buckley P, Morris J, Fisher S, et al. Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. FASEB J. 2014;28:771-80 pubmed publisher
Kim B, Kwon Y, Kim E, So I. Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol. 2013;17:149-56 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Holden N, Gong W, King E, Kaur M, Giembycz M, Newton R. Potentiation of NF-kappaB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Br J Pharmacol. 2007;152:891-902 pubmed

product information

master code :

569

SKU :

0569/10

product name :

(R)-(-)-alpha-Methylhistamine dihydrobromide

unit size :

10 mg (also 50 mg)

description :

Potent, standard H3 agonist

target :

Histamine H3 Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

287

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( R )-(-)- -Methylhistamine dihydrobromide is a very potent, high affinity H3 agonist (KD = 50.3 nM) that displays 200-fold selectivity over H4 receptors. Inhibits H3-mediated histamine synthesis and release in the CNS and stimulates H4-mediated eosinophil shape change (EC50 = 66 nM). . S-enantiomer also available.

top caption :

Potent, standard H3 agonist

extended description :

Potent, standard H3 agonist

chemical name text :

(R)-(-)- -Methyl-1H-imidazole-4-ethanamine dihydrobromide

formula :

C6H11N3.2HBr

formula text :

C6H11N3.2HBr

cas num :

868698-49-1

USD :

186 USD

product details :

Potent, standard H3 agonist

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage