product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Ifenprodil hemitartrate
catalog :
0545
quantity :
10 mg (also 50 mg)
price :
97 USD
more info or order :
citations: 32
Reference |
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Sánchez Blázquez P, Rodríguez Muñoz M, Herrero Labrador R, Burgueno J, Zamanillo D, Garzón J. The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Int J Neuropsychopharmacol. 2014;17:1943-55 pubmed publisher
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Nateri A, Raivich G, Gebhardt C, Da Costa C, Naumann H, Vreugdenhil M, et al. ERK activation causes epilepsy by stimulating NMDA receptor activity. EMBO J. 2007;26:4891-901 pubmed
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Logan S, Partridge J, MATTA J, Buonanno A, Vicini S. Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons. J Neurophysiol. 2007;98:2693-704 pubmed
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Ge S, Yang C, Hsu K, Ming G, Song H. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron. 2007;54:559-66 pubmed
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Kopp C, Longordo F, Nicholson J, Lüthi A. Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function. J Neurosci. 2006;26:12456-65 pubmed
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Amadoro G, Ciotti M, Costanzi M, Cestari V, Calissano P, Canu N. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci U S A. 2006;103:2892-7 pubmed
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Yang C, Huang C, Hsu K. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Neurosci. 2005;25:4288-93 pubmed
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Shin E, Nah S, Kim W, Ko K, Jhoo W, Lim Y, et al. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. Br J Pharmacol. 2005;144:908-18 pubmed
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Ning K, Pei L, Liao M, Liu B, Zhang Y, Jiang W, et al. Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. J Neurosci. 2004;24:4052-60 pubmed
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product information
brand :
Tocris
master code :
0545
SKU :
0545/10
product name :
Ifenprodil hemitartrate
description :
Non-competitive NMDA antagonist; also ligand
target :
NMDA Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
400.49
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NMDA receptor antagonist, acting at the polyamine site. Also an -adrenergic vasodilator. 2 ligand displaying about 3-fold selectivity over 1 sites.
catalog number base :
545
product keywords :
sigma ligand 2 sigma2 1 sigma1 1-adrenoceptor alpha1-adrenoceptor a1-adrenoceptor 1-adrenergic alpha1-adrenergic a1-adrenergic antagonists NMDA polyamine site Receptors Glutamate N-Methyl-D-Aspartate iGluR Ionotropic 23210-5 Adrenergic Alpha-1 Receptors NMDA Receptors Sigma2 Receptors 0545,
extended description :
Non-competitive NMDA antagonist; also ligand
chemical name text :
(1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
formula :
C 21 H 27 NO 2 . C 4 H 6 O 6
formula text :
C21H27NO2.?C4H6O6
2020 USD :
93
2021 USD :
97 USD
storage :
Store at RT
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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