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company name :
Tocris Bioscience
product type :
chemical
product name :
0545/10
catalog :
0545/10
quantity :
10 mg (also 50 mg)
price :
128 USD
more info or order :
citations: 35
Reference
Regan M, Zhu Z, Yuan H, Myers S, Menaldino D, Tahirovic Y, et al. Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors. Nat Commun. 2019;10:321 pubmed publisher
McKay S, Ryan T, McQueen J, Indersmitten T, Marwick K, Hasel P, et al. The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences. Cell Rep. 2018;25:841-851.e4 pubmed publisher
Kashima D, Grueter B. Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior. Proc Natl Acad Sci U S A. 2017;114:8865-8870 pubmed publisher
Grochowska K, Yuanxiang P, Bar J, Raman R, Brugal G, Sahu G, et al. Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Rep. 2017;18:962-981 pubmed publisher
Dolma S, Selvadurai H, Lan X, Lee L, Kushida M, Voisin V, et al. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016;29:859-873 pubmed publisher
Galvez B, Gross N, Sumikawa K. Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats. Neuropharmacology. 2016;105:378-387 pubmed publisher
von Engelhardt J, Bocklisch C, Tönges L, Herb A, Mishina M, Monyer H. GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice. Front Cell Neurosci. 2015;9:95 pubmed publisher
Simma N, Bose T, Kahlfuss S, Mankiewicz J, Lowinus T, Lühder F, et al. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. Cell Commun Signal. 2014;12:75 pubmed publisher
Mirante O, Brandalise F, Bohacek J, Mansuy I. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Front Mol Neurosci. 2014;7:62 pubmed publisher
Sánchez Blázquez P, Rodríguez Muñoz M, Herrero Labrador R, Burgueno J, Zamanillo D, Garzón J. The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Int J Neuropsychopharmacol. 2014;17:1943-55 pubmed publisher
Thomazeau A, Lassalle O, Iafrati J, Souchet B, Guedj F, Janel N, et al. Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a. J Neurosci. 2014;34:1138-47 pubmed publisher
Brady M, Diaz M, Iuso A, Everett J, Valenzuela C, Caldwell K. Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus. J Neurosci. 2013;33:1062-7 pubmed publisher
Pedrazzi M, Averna M, Sparatore B, Patrone M, Salamino F, Marcoli M, et al. Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein. PLoS ONE. 2012;7:e44518 pubmed publisher
El Gaamouch F, Buisson A, Moustié O, Lemieux M, Labrecque S, Bontempi B, et al. Interaction between ?CaMKII and GluN2B controls ERK-dependent plasticity. J Neurosci. 2012;32:10767-79 pubmed publisher
Farinelli M, Heitz F, Grewe B, Tyagarajan S, Helmchen F, Mansuy I. Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection. PLoS ONE. 2012;7:e34047 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Gourley S, Olevska A, Warren M, Taylor J, Koleske A. Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity. J Neurosci. 2012;32:2314-23 pubmed publisher
Heinrich A, Andó R, Turi G, Rozsa B, Sperlagh B. K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol. 2012;167:1003-20 pubmed publisher
Wills T, Klug J, Silberman Y, Baucum A, Weitlauf C, Colbran R, et al. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A. 2012;109:E278-87 pubmed publisher
Hedegaard M, Hansen K, Andersen K, Brauner Osborne H, Traynelis S. Molecular pharmacology of human NMDA receptors. Neurochem Int. 2012;61:601-9 pubmed publisher
McKay S, Griffiths N, Butters P, Thubron E, Hardingham G, Wyllie D. Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. Br J Pharmacol. 2012;166:924-37 pubmed publisher
Roselli F, Livrea P, Almeida O. CDK5 is essential for soluble amyloid ?-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS ONE. 2011;6:e23097 pubmed publisher
Zhang Z, Sun Q. Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons. Dev Neurobiol. 2011;71:221-45 pubmed publisher
Higley M, Sabatini B. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci. 2010;13:958-66 pubmed publisher
Yuan H, Vance K, Junge C, Geballe M, Snyder J, Hepler J, et al. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. J Biol Chem. 2009;284:12862-73 pubmed publisher
Fontaine R, Olivier P, Massonneau V, Leroux P, Degos V, Lebon S, et al. Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits. Proc Natl Acad Sci U S A. 2008;105:16779-84 pubmed publisher
Popp R, Reneau J, Dertien J. Cerebellar granule cells cultured from adolescent rats express functional NMDA receptors: an in vitro model for studying the developing cerebellum. J Neurochem. 2008;106:900-11 pubmed publisher
Nateri A, Raivich G, Gebhardt C, Da Costa C, Naumann H, Vreugdenhil M, et al. ERK activation causes epilepsy by stimulating NMDA receptor activity. EMBO J. 2007;26:4891-901 pubmed
Logan S, Partridge J, MATTA J, Buonanno A, Vicini S. Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons. J Neurophysiol. 2007;98:2693-704 pubmed
Ge S, Yang C, Hsu K, Ming G, Song H. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron. 2007;54:559-66 pubmed
Kopp C, Longordo F, Nicholson J, Lüthi A. Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function. J Neurosci. 2006;26:12456-65 pubmed
Amadoro G, Ciotti M, Costanzi M, Cestari V, Calissano P, Canu N. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci U S A. 2006;103:2892-7 pubmed
Yang C, Huang C, Hsu K. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Neurosci. 2005;25:4288-93 pubmed
Shin E, Nah S, Kim W, Ko K, Jhoo W, Lim Y, et al. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. Br J Pharmacol. 2005;144:908-18 pubmed
Ning K, Pei L, Liao M, Liu B, Zhang Y, Jiang W, et al. Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. J Neurosci. 2004;24:4052-60 pubmed
product information
master code :
545
SKU :
0545/10
product name :
Ifenprodil hemitartrate
unit size :
10 mg (also 50 mg)
description :
Non-competitive NMDA antagonist; also ligand
target :
NMDA Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
400.49
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Ifenprodil hemitartrate is a NMDA receptor antagonist, acting at the polyamine site. Also an -adrenergic vasodilator. 2 ligand displaying about 3-fold selectivity over 1 sites.
top caption :
Non-competitive NMDA antagonist; also ligand
extended description :
Non-competitive NMDA antagonist; also ligand
chemical name text :
(1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
formula :
C21H27NO2. C4H6O6
formula text :
C21H27NO2.?C4H6O6
USD :
128 USD
product details :
Non-competitive NMDA antagonist; also ligand
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK