0542/10 | Tocris Bioscience 0542/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0542/10

catalog :

0542/10

quantity :

10 mg (also 50 mg)

price :

188 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Zhao H, Zhang K, Tang R, Meng H, Zou Y, Wu P, et al. TRPV4 Blockade Preserves the Blood-Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage. Front Mol Neurosci. 2018;11:97 pubmed publisher
Barcomb K, Coultrap S, Bayer K. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Mol Pharmacol. 2013;84:834-43 pubmed publisher
Ludgate L, Ning X, Nguyen D, Adams C, Mentzer L, Hu J. Cyclin-dependent kinase 2 phosphorylates s/t-p sites in the hepadnavirus core protein C-terminal domain and is incorporated into viral capsids. J Virol. 2012;86:12237-50 pubmed publisher
Belmeguenai A, Hansel C. A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation. J Neurosci. 2005;25:10768-72 pubmed

product information

master code :

542

SKU :

0542/10

product name :

H-7 dihydrochloride

unit size :

10 mg (also 50 mg)

description :

Protein kinase inhibitor

target :

Broad Spectrum Protein Kinase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

364.29

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

H-7 dihydrochloride is a protein kinase inhibitor (IC50 values for inhibition of PKA, PKG, PKC and myosin light chain kinase are 3.0, 5.8, 6.0 and 97.0 M, respectively. H-7 shows antiviral activity against influenza A (IC50 = 10 M) in vitro . H-7 also inhibits interleukin-stimulated secretion of IgM and blocks PMA -stimulated interleukin 1 production.

top caption :

Protein kinase inhibitor

extended description :

Protein kinase inhibitor

chemical name text :

( )-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride

formula :

C14H17N3O2S.2HCl

formula text :

C14H17N3O2S.2HCl

cas num :

108930-17-2

USD :

188 USD

product details :

Protein kinase inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage