0541/10 | Tocris Bioscience 0541/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0541/10

catalog :

0541/10

quantity :

10 mg (also 50 mg)

price :

211 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, et al. Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties. Nat Mater. 2020;19:797-806 pubmed publisher
Pitha I, Oglesby E, Chow A, Kimball E, Pease M, Schaub J, et al. Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma. Transl Vis Sci Technol. 2018;7:6 pubmed publisher
Fazakas C, Nagaraj C, Zabini D, Végh A, Marsh L, Wilhelm I, et al. Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension. Front Physiol. 2018;9:537 pubmed publisher
Bailey T, Luan H, Tom E, Bielecki T, Mohapatra B, Ahmad G, et al. A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells. J Biol Chem. 2014;289:30443-58 pubmed publisher
Flavahan S, Flavahan N. The atypical structure and function of newborn arterial endothelium is mediated by Rho/Rho kinase signaling. Am J Physiol Heart Circ Physiol. 2014;307:H628-32 pubmed publisher
Akhtar S, Yousif M, Dhaunsi G, Sarkhouh F, Chandrasekhar B, Attur S, et al. Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction. PLoS ONE. 2013;8:e67813 pubmed publisher
Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, et al. Inhibition of TNF-? improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes. 2012;61:2134-45 pubmed publisher
Jeyaraj S, Unger N, Eid A, Mitra S, Paul El Dahdah N, Quilliam L, et al. Cyclic AMP-Rap1A signaling activates RhoA to induce ?(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells. Am J Physiol Cell Physiol. 2012;303:C499-511 pubmed publisher
Lim M, Choi S, Cho Y, Yeon S, Kim E, Ahn D, et al. The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. PLoS ONE. 2012;7:e35177 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Rodrigues Díez R, Rodrígues Díez R, Lavoz C, Rayego Mateos S, Civantos E, Rodriguez Vita J, et al. Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-?-independent process. PLoS ONE. 2010;5:e14145 pubmed publisher
Choi S, Ahn D, Lee Y. Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. Cardiovasc Res. 2009;82:324-32 pubmed publisher
Takehara T, Teramura T, Onodera Y, Kakegawa R, Fukunaga N, Takenoshita M, et al. Rho-associated kinase inhibitor Y-27632 promotes survival of cynomolgus monkey embryonic stem cells. Mol Hum Reprod. 2008;14:627-34 pubmed publisher
Inan S, Buyukafsar K. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. Br J Pharmacol. 2008;155:44-51 pubmed publisher
Scherer E, Arnold W, Wangemann P. Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss. BMC Ear Nose Throat Disord. 2005;5:10 pubmed
Rodriguez Vita J, Ruiz Ortega M, Ruperez M, Esteban V, Sanchez Lopez E, Plaza J, et al. Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circ Res. 2005;97:125-34 pubmed
Wibberley A, Chen Z, Hu E, Hieble J, Westfall T. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle. Br J Pharmacol. 2003;138:757-66 pubmed

product information

master code :

541

SKU :

0541/10

product name :

Fasudil hydrochloride

unit size :

10 mg (also 50 mg)

description :

Inhibitor of cyclic nucleotide dependent- and Rho-kinases

target :

Rho-kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

327.83

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Fasudil hydrochloride is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 M). Fasudil suppresses MMP-2 expression and induces apoptosis in glioblastoma cells in vivo . Fasudil is a Ca2+ antagonist, vasodilator and inhibits proliferation of vascular smooth muscle cells. Fasudil binds to -synuclein to reduce aggregate formation in cellular models of Parkinson s disease, also displays neuroprotective properties and increases survival of dopaminergic neurons in vivo .

top caption :

Inhibitor of cyclic nucleotide dependent- and Rho-kinases

extended description :

Inhibitor of cyclic nucleotide dependent- and Rho-kinases

formula :

C14H17N3O2S.HCl

formula text :

C14H17N3O2S.HCl

cas num :

105628-07-7

USD :

211 USD

product details :

Inhibitor of cyclic nucleotide dependent- and Rho-kinases

alt names :

HA 1077

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage