product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
8-Hydroxy-DPAT hydrobromide
catalog :
0529
quantity :
10 mg (also 50 mg)
price :
75 USD
more info or order :
citations: 27
Reference
Gadgaard C, Jensen A. Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2020;175:113870 pubmed publisher
Nguyen H, Cho D, Jang S, Han S, Park S. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol. 2019;23:271-279 pubmed publisher
Walory J, Mielczarek L, Jarończyk M, Koronkiewicz M, Kossakowski J, Bugno R, et al. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands. Int J Mol Sci. 2018;19: pubmed publisher
Carvalho Dias E, Miranda A, Martinho O, Mota P, Costa A, Nogueira Silva C, et al. Serotonin regulates prostate growth through androgen receptor modulation. Sci Rep. 2017;7:15428 pubmed publisher
Majeed Z, Abdeljaber E, Soveland R, Cornwell K, Bankemper A, Koch F, et al. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast. 2016;2016:7291438 pubmed publisher
Yin L, Rasch M, He Q, Wu S, Dou F, Shu Y. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cereb Cortex. 2017;27:509-521 pubmed publisher
Tullis B, Ryals R, Coyner A, Gale M, Nicholson A, Ku C, et al. Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2015;56:4560-9 pubmed publisher
Watts S, Darios E, Seitz B, Thompson J. 5-HT is a potent relaxant in rat superior mesenteric veins. Pharmacol Res Perspect. 2015;3:e00103 pubmed publisher
Shelton J, Yun S, Losee Olson S, Turek F, Bonaventure P, Dvorak C, et al. Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity. Front Behav Neurosci. 2014;8:453 pubmed publisher
McAllister C, Mi Z, Mure M, Li Q, Muma N. GPER1 stimulation alters posttranslational modification of RGSz1 and induces desensitization of 5-HT1A receptor signaling in the rat hypothalamus. Neuroendocrinology. 2014;100:228-39 pubmed publisher
Richardson K, Shelton K. N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas. J Pharmacol Exp Ther. 2015;352:156-65 pubmed publisher
Bonchak J, Eby J, Willenborg K, Chrobak D, Henning S, Krzywiec A, et al. Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin. Arch Biochem Biophys. 2014;563:71-8 pubmed publisher
Khatri N, Simpson K, Lin R, Paul I. Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology (Berl). 2014;231:1191-200 pubmed publisher
Araragi N, Mlinar B, Baccini G, Gutknecht L, Lesch K, Corradetti R. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Front Pharmacol. 2013;4:97 pubmed publisher
Fuss J, Vogt M, Weber K, Burke T, Gass P, Hensler J. Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running. Synapse. 2013;67:648-55 pubmed publisher
Ishima T, Iyo M, Hashimoto K. Neurite outgrowth mediated by the heat shock protein Hsp90?: a novel target for the antipsychotic drug aripiprazole. Transl Psychiatry. 2012;2:e170 pubmed publisher
Rock E, Bolognini D, Limebeer C, Cascio M, Anavi Goffer S, Fletcher P, et al. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. Br J Pharmacol. 2012;165:2620-34 pubmed publisher
Murray K, Stephens M, Rank M, D Amico J, Gorassini M, Bennett D. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011;106:925-43 pubmed publisher
Manzke T, Niebert M, Koch U, Caley A, Vogelgesang S, Hülsmann S, et al. Serotonin receptor 1A-modulated phosphorylation of glycine receptor ?3 controls breathing in mice. J Clin Invest. 2010;120:4118-28 pubmed publisher
Rawls S, Shah H, Ayoub G, Raffa R. 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians. Neurosci Lett. 2010;484:113-7 pubmed publisher
Duncan M, Hester J, Hopper J, Franklin K. The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors. Eur J Neurosci. 2010;31:1646-54 pubmed publisher
Rossi D, Dai Y, Thomas P, Carrasco G, Doncarlos L, Muma N, et al. Estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the hypothalamus is independent of estrogen receptor-beta. Psychoneuroendocrinology. 2010;35:1023-33 pubmed publisher
Hensler J, Vogt M, Gass P. Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice. Psychoneuroendocrinology. 2010;35:469-74 pubmed publisher
Manzke T, Dutschmann M, Schlaf G, Mörschel M, Koch U, Ponimaskin E, et al. Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci. 2009;364:2589-602 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher
Pagano M, Jordan J, Neves S, Nguyen T, Iyengar R. Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways. Cell Signal. 2008;20:1190-7 pubmed publisher
Maciag D, Coppinger D, Paul I. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development. Brain Res. 2006;1125:171-5 pubmed
product information
brand :
Tocris
master code :
0529
SKU :
0529/10
product name :
8-Hydroxy-DPAT hydrobromide
description :
Selective 5-HT1A agonist; also has moderate affinity for 5-HT7
target :
5-HT1 Receptor Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
328.29
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo . . R-enantiomer and 7-Hydroxy Isomer also available.
catalog number base :
529
product keywords :
moderate affinity 5-HT7 5-HT1A agonists Selective Serotonin Receptors 5-Hydroxytryptamine 5-HT1 8-OH-DPAT hydrobromide 5-HT7 Receptors 5-HT1A Receptors 0529,
extended description :
Selective 5-HT1A agonist; also has moderate affinity for 5-HT7
chemical name text :
( )-8-Hydroxy-2-dipropylaminotetralin hydrobromide
formula :
C 16 H 25 NO.HBr
formula text :
C16H25NO.HBr
cas num :
76135-31-4
2020 USD :
72
2021 USD :
75 USD
alt names :
8-OH-DPAT hydrobromide
storage :
Desiccate at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK