product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0513/10
catalog :
0513/10
quantity :
10 mg (also 50 mg)
price :
176 USD
more info or order :
citations: 5
Reference
Matsui A, Alvarez V. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep. 2018;23:3852-3863 pubmed publisher
Masi A, Narducci R, Landucci E, Moroni F, Mannaioni G. MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons. Br J Pharmacol. 2013;169:130-42 pubmed publisher
Ferreira S, Teixeira F, Garção P, Agostinho P, Ledent C, Cortes L, et al. Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. Neurochem Int. 2012;61:219-26 pubmed publisher
Ferraro L, Frankowska M, Marcellino D, Zaniewska M, Beggiato S, Filip M, et al. A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology. 2012;37:1856-66 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
product information
master code :
513
SKU :
0513/10
product name :
GBR 12783 dihydrochloride
unit size :
10 mg (also 50 mg)
description :
Potent and selective DA uptake inhibitor
target :
Dopamine Transporter Inhibitors
category :
Small Molecules
purity :
99%
observed molecular weight :
485.5
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
GBR 12783 dihydrochloride is a very potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).
top caption :
Potent and selective DA uptake inhibitor
extended description :
Potent and selective DA uptake inhibitor
chemical name text :
1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride
formula :
C28H32N2O.2HCl
formula text :
C28H32N2O.2HCl
cas num :
67469-75-4
USD :
176 USD
product details :
Potent and selective DA uptake inhibitor
storage :
Desiccate at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK