Dantrolene, sodium salt | Tocris Bioscience 0507 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Dantrolene, sodium salt

catalog :

0507

quantity :

100 mg

price :

85 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Battefeld A, Popovic M, de Vries S, Kole M. High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep. 2019;26:182-191.e5 pubmed publisher
Florea A, Varghese E, McCallum J, Mahgoub S, Helmy I, Varghese S, et al. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget. 2017;8:22876-22893 pubmed publisher
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher
Lin T, Lu C, Wu C, Huang S, Wang S. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Int J Mol Sci. 2015;16:5555-71 pubmed publisher
Efthymiou A, Steiner J, Pavan W, Wincovitch S, Larson D, Porter F, et al. Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. Stem Cells Transl Med. 2015;4:230-8 pubmed publisher
Wang Y, Chen Y, Cheng R, Huang R. Role of Naâº/CaÂ²âº exchanger in CaÂ²âº homeostasis in rat suprachiasmatic nucleus neurons. J Neurophysiol. 2015;113:2114-26 pubmed publisher
Patel J, Witkovsky P, Avshalumov M, Rice M. Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release. J Neurosci. 2009;29:6568-79 pubmed publisher
Drdla R, Sandkühler J. Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo. Mol Pain. 2008;4:18 pubmed publisher
Wieland H, Hechtel N, Faigle M, Neumeister B. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. FEMS Immunol Med Microbiol. 2006;47:296-301 pubmed

product information

brand :

Tocris

master code :

0507

SKU :

0507/100

product name :

Dantrolene, sodium salt

description :

Ca2+ release inhibitor

target :

Ryanodine Receptor Inhibitors

category :

Small Molecules

unit size :

100 mg

purity :

98%

observed molecular weight :

336.23

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

catalog number base :

507

product keywords :

Ca2+ release inhibitors inhibits Calcium Signaling Signalling Agents General ryanodine receptors ion channels General Calcium Signaling Agents Ryanodine Receptors 0507, Ryanodine receptors, RyRs, RyR

extended description :

Ca2+ release inhibitor

chemical name text :

1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt

formula :

C 14 H 9 N 4 NaO 5

formula text :

C14H9N4NaO5

cas num :

14663-23-1

2020 USD :

2021 USD :

85 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage