0504/10 | Tocris Bioscience 0504/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0504/10

catalog :

0504/10

quantity :

10 mg (also 50 mg)

price :

146 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Kim J, Kim D, Heo H, Choi S, Hong S, Kim W. Role of miRNA-181a-2-3p in cadmium-induced inflammatory responses of human bronchial epithelial cells. J Thorac Dis. 2019;11:3055-3069 pubmed publisher
Schweikl H, Gallorini M, Forstner M, Petzel C, Bolay C, Hiller K, et al. Flavin-containing enzymes as a source of reactive oxygen species in HEMA-induced apoptosis. Dent Mater. 2017;33:e255-e271 pubmed publisher
Gonsalves C, Crable S, Chandra S, Li W, Kalra V, Joiner C. Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1?. Am J Hematol. 2014;89:273-81 pubmed publisher
Knight J, Zhao W, Luo W, Subramanian V, O Dell A, Yalavarthi S, et al. Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus. J Clin Invest. 2013;123:2981-93 pubmed publisher
Leoni G, Alam A, Neumann P, Lambeth J, Cheng G, McCoy J, et al. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest. 2013;123:443-54 pubmed publisher
Ruparel S, Henry M, AKOPIAN A, Patil M, Zeldin D, Roman L, et al. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. Pain. 2012;153:2031-9 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher

product information

master code :

504

SKU :

0504/10

product name :

Diphenyleneiodonium chloride

unit size :

10 mg (also 50 mg)

description :

GPR3 agonist; also inhibits NOS and NADPH oxidases

target :

Additional Nitric Oxide Compounds

category :

Small Molecules

purity :

99%

observed molecular weight :

314.55

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Diphenyleneiodonium chloride is a GPR3 agonist (EC50 = 1 M); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and -arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.

top caption :

GPR3 agonist; also inhibits NOS and NADPH oxidases

extended description :

GPR3 agonist; also inhibits NOS and NADPH oxidases

chemical name text :

[1,1 -Biphenyl]-2,2 -diyliodonium chloride

formula :

C12H8ClI

formula text :

C12H8ClI

cas num :

4673-26-1

USD :

146 USD

product details :

GPR3 agonist; also inhibits NOS and NADPH oxidases

alt names :

DPI

storage :

Desiccate at -20░C

more info or order :

Tocris Bioscience product webpage