product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0495/25
catalog :
0495/25
quantity :
25 mg
price :
204 USD
more info or order :
citations: 10
Reference
Pirino B, Spodnick M, Gargiulo A, Curtis G, Barson J, Karkhanis A. Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis. Neuropharmacology. 2020;181:108341 pubmed publisher
Li X, Sun Y, Jin Q, Song D, Diao Y. Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathway. Int J Mol Med. 2019;44:1866-1876 pubmed publisher
Dziedowiec E, Nayak S, Gruver K, Jennings T, Tallarida C, Rawls S. Mu Opioid Receptor Agonist DAMGO Produces Place Conditioning, Abstinence-induced Withdrawal, and Naltrexone-Dependent Locomotor Activation in Planarians. Neuroscience. 2018;386:214-222 pubmed publisher
Liu J, Sharma K, Zangrandi L, Chen C, Humphrey S, Chiu Y, et al. In vivo brain GPCR signaling elucidated by phosphoproteomics. Science. 2018;360: pubmed publisher
Polter A, Barcomb K, Chen R, Dingess P, Graziane N, Brown T, et al. Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress. elife. 2017;6: pubmed publisher
Zhou L, Lovell K, Frankowski K, Slauson S, Phillips A, Streicher J, et al. Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem. 2013;288:36703-16 pubmed publisher
Kharmate G, Rajput P, Lin Y, Kumar U. Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int. 2013;13:93 pubmed publisher
Grachev P, Li X, Lin Y, Hu M, Elsamani L, Paterson S, et al. GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. PLoS ONE. 2012;7:e44344 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Marchant N, Furlong T, McNally G. Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinction. J Neurosci. 2010;30:14102-15 pubmed publisher
product information
master code :
495
SKU :
0495/25
product name :
(+/-)-U-50488 hydrochloride
unit size :
25 mg
description :
Selective agonist
target :
Kappa Opioid Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
405.79
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( )-U-50488 hydrochloride is a selective -opioid agonist. At higher concentrations blocks Na+ channels. . (-)-enantiomer and (+)-enantiomer also available.
top caption :
Selective agonist
extended description :
Selective agonist
chemical name text :
trans-( )-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
formula :
C19H26Cl2N2O.HCl
formula text :
C19H26Cl2N2O.HCl
cas num :
67197-96-0
USD :
204 USD
product details :
Selective agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK