AG 18 | Tocris Bioscience 0493/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AG 18

catalog :

0493/10

quantity :

10 mg (also 50 mg)

price :

129 USD

citations: 1

Reference
Villalba N, Stankevicius E, García Sacristán A, Simonsen U, Prieto D. Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries. Am J Physiol Heart Circ Physiol. 2007;292:H1157-69 pubmed

product information

brand :

Tocris

MasterCode :

493

SKU :

0493/10

product name :

AG 18

unit sizes :

10 mg (also 50 mg)

description :

EGFR/PDGFR-kinase inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

observed molecular weight :

186.17

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AG 18 is an inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 u M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.

extended description :

EGFR/PDGFR-kinase inhibitor

chemical name text :

[(3,4-Dihydroxyphenyl)methylene]-propenedinitrile

formula :

C 10 H 6 N 2 O 2

formula text :

C10H6N2O2

cas num :

118409-57-7

USD :

129 USD

product details :

EGFR/PDGFR-kinase inhibitor

alt names :

RG-50810, Tyrphostin A23

storage :

Desiccate at +4°C