product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0482/50
catalog :
0482/50
quantity :
50 mg
price :
185 USD
more info or order :
citations: 17
Reference
Emmerson E, May A, Nathan S, Cruz Pacheco N, Lizama C, Maliskova L, et al. SOX2 regulates acinar cell development in the salivary gland. elife. 2017;6: pubmed publisher
Wallace A, Gabriel D, McHale N, Hollywood M, Thornbury K, Sergeant G. Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine. Physiol Rep. 2015;3: pubmed publisher
Pacini L, De Falco E, Di Bari M, Coccia A, Siciliano C, Ponti D, et al. M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther. 2014;15:1489-98 pubmed publisher
Fonseca B, Martínez Águila A, Díaz Hernández M, Pintor J. Diadenosine tetraphosphate contributes to carbachol-induced tear secretion. Purinergic Signal. 2015;11:87-93 pubmed publisher
Nedvetsky P, Emmerson E, Finley J, Ettinger A, Cruz Pacheco N, Prochazka J, et al. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014;30:449-62 pubmed publisher
Mans R, Warmus B, Smith C, McMahon L. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol. 2014;112:2388-97 pubmed publisher
Placeres Uray F, Febres Aldana C, Fernandez Ruiz R, González de Alfonzo R, Lippo de Becemberg I, Alfonzo M. M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation. World Allergy Organ J. 2013;6:22 pubmed publisher
Jahchan N, Dudley J, Mazur P, Flores N, Yang D, Palmerton A, et al. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 2013;3:1364-77 pubmed publisher
Hodges R, Bair J, Carozza R, Li D, Shatos M, Dartt D. Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res. 2012;103:99-113 pubmed publisher
Kajiya M, Ichimonji I, Min C, Zhu T, Jin J, Yu Q, et al. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. Mol Pharmacol. 2012;82:115-24 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, et al. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem. 2012;287:5059-69 pubmed publisher
Matsumoto Y, Miyazato M, Furuta A, Torimoto K, Hirao Y, Chancellor M, et al. Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats. Urology. 2010;75:862-7 pubmed publisher
Kitazawa T, Asakawa K, Nakamura T, Teraoka H, Unno T, Komori S, et al. M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. J Pharmacol Exp Ther. 2009;330:487-93 pubmed publisher
Solanki P, Cuprian Beltechi A, Cunnane T. Cholinergic innervation of the guinea-pig isolated vas deferens. Naunyn Schmiedebergs Arch Pharmacol. 2007;376:265-74 pubmed
Clancy S, Boyer S, Slesinger P. Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. J Neurosci. 2007;27:6388-99 pubmed
Howell G, West L, Jenkins C, Lineberry B, Yokum D, Rockhold R. In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine. BMC Pharmacol. 2005;5:13 pubmed publisher
product information
master code :
482
SKU :
0482/50
product name :
4-DAMP
unit size :
50 mg
description :
Muscarinic M3 antagonist
target :
mAChR M3 Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
451.33
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
4-DAMP is an antagonist at the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors.
top caption :
Muscarinic M3 antagonist
extended description :
Muscarinic M3 antagonist
chemical name text :
1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide
formula :
C21H26INO2
formula text :
C21H26INO2
cas num :
1952-15-4
USD :
185 USD
product details :
Muscarinic M3 antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK