product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
(E)-Capsaicin
catalog :
0462
quantity :
100 mg
price :
142 USD
more info or order :
citations: 38
Reference |
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Wang C, Sun D, Liu C, Zhu C, Jing X, Chen S, et al. Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complet Freund's Adjuvant-induced mice: roles of dynorpin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel. J Transl Med. 2015;13:284 pubmed publisher
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Nash M, McIntyre P, Groarke A, Lilley E, Culshaw A, Hallett A, et al. 7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hyp. J Pharmacol Exp Ther. 2012;342:389-98 pubmed publisher
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Benninger F, Freund T, Hajos N. Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice. Neurochem Int. 2008;52:89-94 pubmed
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Pitcher M, Price T, Entrena J, Cervero F. Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia. Mol Pain. 2007;3:17 pubmed
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Bautista D, Movahed P, Hinman A, Axelsson H, Sterner O, Hogestatt E, et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A. 2005;102:12248-52 pubmed
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Ahern G, Brooks I, Miyares R, Wang X. Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J Neurosci. 2005;25:5109-16 pubmed
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Melis M, Pistis M, Perra S, Muntoni A, Pillolla G, Gessa G. Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors. J Neurosci. 2004;24:53-62 pubmed
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Bang R, Biburger M, Neuhuber W, Tiegs G. Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage. J Pharmacol Exp Ther. 2004;308:1174-80 pubmed
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Smart D, Jonsson K, Vandevoorde S, Lambert D, Fowler C. 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. Br J Pharmacol. 2002;136:452-8 pubmed
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Craib S, Ellington H, Pertwee R, Ross R. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. Br J Pharmacol. 2001;134:30-7 pubmed
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Izzo A, Capasso R, Pinto L, Di Carlo G, Mascolo N, Capasso F. Effect of vanilloid drugs on gastrointestinal transit in mice. Br J Pharmacol. 2001;132:1411-6 pubmed
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product information
brand :
Tocris
master code :
0462
SKU :
0462/100
product name :
(E)-Capsaicin
description :
TRPV agonist
target :
TRPV Agonists
category :
Small Molecules
unit size :
100 mg
purity :
98%
observed molecular weight :
305.42
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Prototypic vanilloid receptor agonist (pEC50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets.
catalog number base :
462
product keywords :
Prototypic vanilloid receptor agonists Vanillioid Receptors VR1 TRPV TRP Channels Transient Receptor Potential TRPV 0462,
extended description :
TRPV agonist
chemical name text :
(E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
formula :
C 18 H 27 NO 3
formula text :
C18H27NO3
cas num :
404-86-4
2020 USD :
135
2021 USD :
142 USD
storage :
Store at RT
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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