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company name :
Tocris Bioscience
product type :
chemical
product name :
0462/100
catalog :
0462/100
quantity :
100 mg
price :
185 USD
more info or order :
citations: 42
Reference
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Chen J, Varga A, Selvarajah S, Jenes A, Dienes B, Sousa Valente J, et al. Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk. Sci Rep. 2016;6:33307 pubmed publisher
Chen C, Lu M, Pan Q, Fichna J, Zheng L, Wang K, et al. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. PLoS ONE. 2015;10:e0145556 pubmed publisher
Wang C, Sun D, Liu C, Zhu C, Jing X, Chen S, et al. Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complet Freund's Adjuvant-induced mice: roles of dynorpin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel. J Transl Med. 2015;13:284 pubmed publisher
Zakharov A, Vitale C, Kilinc E, Koroleva K, Fayuk D, Shelukhina I, et al. Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers. Front Cell Neurosci. 2015;9:287 pubmed publisher
Stanley C, Hind W, Tufarelli C, O Sullivan S. Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation. Cardiovasc Res. 2015;107:568-78 pubmed publisher
Shi H, Liu C, Ding L, Zheng Y, Fei X, Lu L, et al. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. World J Gastroenterol. 2015;21:4852-63 pubmed publisher
Ma X, Zhang F, Dong F, Bao L, Zhang X. Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin. Mol Pain. 2015;11:22 pubmed publisher
Rossi S, Motta C, Studer V, Macchiarulo G, Volpe E, Barbieri F, et al. Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. Mol Neurodegener. 2014;9:56 pubmed publisher
Wang G, Wang X, Liu S, Qu M, Xia Y, Needleman B, et al. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol. 2014;307:G719-31 pubmed publisher
Nguyen T, Kwon S, Hong S, Ma S, Jung Y, Hwang J, et al. Transient receptor potential vanilloid type 1 channel may modulate opioid reward. Neuropsychopharmacology. 2014;39:2414-22 pubmed publisher
Wilhelmsen K, Khakpour S, Tran A, Sheehan K, Schumacher M, Xu F, et al. The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells. J Biol Chem. 2014;289:13079-100 pubmed publisher
Chen C, Fichna J, Laudon M, Storr M. Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. World J Gastroenterol. 2014;20:1298-304 pubmed publisher
Hartley T, Stevens B, Ahuja K, Ball M. Development and experimental application of an HPLC procedure for the determination of capsaicin and dihydrocapsaicin in serum samples from human subjects. Indian J Clin Biochem. 2013;28:329-35 pubmed publisher
Chiu I, Heesters B, Ghasemlou N, von Hehn C, Zhao F, Tran J, et al. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013;501:52-7 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher
Fairless R, Beck A, Kravchenko M, Williams S, Wissenbach U, Diem R, et al. Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS ONE. 2013;8:e58260 pubmed publisher
Nesuashvili L, Hadley S, Bahia P, Taylor Clark T. Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol. 2013;83:1007-19 pubmed publisher
Motter A, Ahern G. TRPA1 is a polyunsaturated fatty acid sensor in mammals. PLoS ONE. 2012;7:e38439 pubmed publisher
Nash M, McIntyre P, Groarke A, Lilley E, Culshaw A, Hallett A, et al. 7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hyp. J Pharmacol Exp Ther. 2012;342:389-98 pubmed publisher
Gao H, Miyata K, Bhaskaran M, Derbenev A, Zsombok A. Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse. Diabetes. 2012;61:1381-90 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Martinez Garcia E, Leopoldo M, Lacivita E, Terrón J. Increase of capsaicin-induced trigeminal Fos-like immunoreactivity by 5-HT(7) receptors. Headache. 2011;51:1511-9 pubmed publisher
Zsombok A, Bhaskaran M, Gao H, Derbenev A, Smith B. Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. J Neurosci. 2011;31:14024-31 pubmed publisher
Khatibi N, Jadhav V, Charles S, Chiu J, Buchholz J, Tang J, et al. Capsaicin pre-treatment provides neurovascular protection against neonatal hypoxic-ischemic brain injury in rats. Acta Neurochir Suppl. 2011;111:225-30 pubmed publisher
Westlund K, Kochukov M, Lu Y, McNearney T. Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior. Mol Pain. 2010;6:46 pubmed publisher
Bhaskaran M, Smith B. Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy. Exp Neurol. 2010;223:529-36 pubmed publisher
Buznikov G, Nikitina L, Bezuglov V, Francisco M, Boysen G, Obispo Peak I, et al. A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci. 2010;32:1-18 pubmed publisher
Cobellis G, Ricci G, Cacciola G, Orlando P, Petrosino S, Cascio M, et al. A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up. Biol Reprod. 2010;82:451-8 pubmed publisher
Gibson H, Edwards J, Page R, Van Hook M, Kauer J. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron. 2008;57:746-59 pubmed publisher
Benninger F, Freund T, Hajos N. Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice. Neurochem Int. 2008;52:89-94 pubmed
Pitcher M, Price T, Entrena J, Cervero F. Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia. Mol Pain. 2007;3:17 pubmed
Bautista D, Movahed P, Hinman A, Axelsson H, Sterner O, Hogestatt E, et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A. 2005;102:12248-52 pubmed
Ahern G, Brooks I, Miyares R, Wang X. Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J Neurosci. 2005;25:5109-16 pubmed
Melis M, Pistis M, Perra S, Muntoni A, Pillolla G, Gessa G. Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors. J Neurosci. 2004;24:53-62 pubmed
Bang R, Biburger M, Neuhuber W, Tiegs G. Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage. J Pharmacol Exp Ther. 2004;308:1174-80 pubmed
Smart D, Jonsson K, Vandevoorde S, Lambert D, Fowler C. 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. Br J Pharmacol. 2002;136:452-8 pubmed
Craib S, Ellington H, Pertwee R, Ross R. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. Br J Pharmacol. 2001;134:30-7 pubmed
Izzo A, Capasso R, Pinto L, Di Carlo G, Mascolo N, Capasso F. Effect of vanilloid drugs on gastrointestinal transit in mice. Br J Pharmacol. 2001;132:1411-6 pubmed
image
image 1 :
Tocris Bioscience 0462/100 image 1
Cat.No. 0462 - (E)-Capsaicin C18H27NO3 CAS No. 404-86-4
product information
master code :
462
SKU :
0462/100
product name :
(E)-Capsaicin
unit size :
100 mg
description :
TRPV agonist
target :
TRPV Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
305.42
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( E )-Capsaicin is a prototypic vanilloid receptor agonist (pEC50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets.
top caption :
TRPV agonist
extended description :
TRPV agonist
chemical name text :
(E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
formula :
C18H27NO3
formula text :
C18H27NO3
cas num :
404-86-4
USD :
185 USD
product details :
TRPV agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK