product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0458/10
catalog :
0458/10
quantity :
10 mg (also 50 mg)
price :
272 USD
more info or order :
citations: 15
Reference
Bijata M, Labus J, Guseva D, Stawarski M, Butzlaff M, Dzwonek J, et al. Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix. Cell Rep. 2017;19:1767-1782 pubmed publisher
Sargin D, Oliver D, Lambe E. Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels. elife. 2016;5: pubmed publisher
Chan J, McCorvy J, Acharya S, Johns M, Day T, Roth B, et al. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. PLoS Pathog. 2016;12:e1005651 pubmed publisher
Montalbano A, Corradetti R, Mlinar B. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PLoS ONE. 2015;10:e0140369 pubmed publisher
Chien C, Su M. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. J Biomed Sci. 2015;22:42 pubmed publisher
Gantz S, Bunzow J, Williams J. Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Neuron. 2013;78:807-12 pubmed publisher
Kim J, Bridle B, Ghia J, Wang H, Syed S, Manocha M, et al. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. J Immunol. 2013;190:4795-804 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Murray K, Stephens M, Rank M, D Amico J, Gorassini M, Bennett D. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011;106:925-43 pubmed publisher
Manzke T, Dutschmann M, Schlaf G, Mörschel M, Koch U, Ponimaskin E, et al. Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci. 2009;364:2589-602 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher
Seeburg D, Liu X, Chen C. Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci. 2004;24:10950-62 pubmed
MacLean M, Morecroft I. Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy. Br J Pharmacol. 2001;134:614-20 pubmed
Morecroft I, Heeley R, Prentice H, Kirk A, MacLean M. 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Br J Pharmacol. 1999;128:730-4 pubmed
Geerts I, Matthys K, Herman A, Bult H. Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol. 1999;127:1327-36 pubmed
product information
master code :
458
SKU :
0458/10
product name :
5-Carboxamidotryptamine maleate
unit size :
10 mg (also 50 mg)
description :
5-HT1 agonist; also has high affinity for 5-ht5a and 5-HT7
target :
Non-selective 5-HT1 Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
319.32
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
5-Carboxamidotryptamine maleate is a 5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B, 5-HT1D, 5-ht5 and 5-HT7 receptors.
top caption :
5-HT1 agonist; also has high affinity for 5-ht5a and 5-HT7
extended description :
5-HT1 agonist; also has high affinity for 5-ht5a and 5-HT7
formula :
C11H13N3O.C4H4O4
formula text :
C11H13N3O.C4H4O4
cas num :
74885-72-6
USD :
272 USD
product details :
5-HT1 agonist; also has high affinity for 5-ht5a and 5-HT7
alt names :
AH-21467,5-CT
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK