0452/500 | Tocris Bioscience 0452/500 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0452/500

catalog :

0452/500

quantity :

500 mg

price :

167 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
da Costa R, Fais R, Dechandt C, Louzada Junior P, Alberici L, Lobato N, et al. Increased mitochondrial ROS generation mediates the loss of the anti-contractile effects of perivascular adipose tissue in high-fat diet obese mice. Br J Pharmacol. 2017;174:3527-3541 pubmed publisher
Guo L, Eldridge S, Furniss M, Mussio J, DAVIS M. Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways. Curr Protoc Chem Biol. 2015;7:141-185 pubmed publisher
Purnell P, Fox H. Efavirenz induces neuronal autophagy and mitochondrial alterations. J Pharmacol Exp Ther. 2014;351:250-8 pubmed publisher
Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey M, Kuum M, et al. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy. 2014;10:1105-19 pubmed publisher
Chouhan A, Zhang J, Zinsmaier K, MacLeod G. Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ but exert little influence as Ca2+ buffers at nerve firing rates in situ. J Neurosci. 2010;30:1869-81 pubmed publisher

product information

master code :

452

SKU :

0452/500

product name :

CCCP

unit size :

500 mg

description :

Oxidative phosphorylation uncoupler

target :

Oxidative Phosphorylation Uncouplers

category :

Small Molecules

purity :

98%

observed molecular weight :

204.62

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CCCP is a protonophore. It disrupts mitochondria membrane potential by transporting protons across the mitochondrial inner membrane, which interferes with the proton gradient and ATP synthesis. CCCP is a widely used as an uncoupler of oxidative phosphorylation to induce mitochondrial depolarization.

top caption :

Oxidative phosphorylation uncoupler

extended description :

Oxidative phosphorylation uncoupler

chemical name text :

Carbonyl cyanide 3-chlorophenylhydrazone

formula :

C9H5ClN4

formula text :

C9H5ClN4

cas num :

555-60-2

USD :

167 USD

product details :

Oxidative phosphorylation uncoupler

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage