Calpeptin | Tocris Bioscience 0448 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Calpeptin

catalog :

0448

quantity :

10 mg (also 50 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Zhou Y, Cai L. Calpeptin Reduces Neurobehavioral Deficits and Neuronal Apoptosis Following Subarachnoid Hemorrhage in Rats. J Stroke Cerebrovasc Dis. 2019;28:125-132 pubmed publisher
Rivera Pagán A, Rivera Aponte D, Melnik Martinez K, Zayas Santiago A, Kucheryavykh L, Martins A, et al. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia. PLoS ONE. 2015;10:e0125195 pubmed publisher
Machado V, Morte M, Carreira B, Azevedo M, Takano J, Iwata N, et al. Involvement of calpains in adult neurogenesis: implications for stroke. Front Cell Neurosci. 2015;9:22 pubmed publisher
Zakharova N, Artemenko E, Podoplelova N, Sveshnikova A, Demina I, Ataullakhanov F, et al. Platelet surface-associated activation and secretion-mediated inhibition of coagulation factor XII. PLoS ONE. 2015;10:e0116665 pubmed publisher
Wang W, Zhang F, Li L, Tang F, Siedlak S, Fujioka H, et al. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons. J Biol Chem. 2015;290:168-82 pubmed publisher
Redpath G, Woolger N, Piper A, Lemckert F, Lek A, Greer P, et al. Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair. Mol Biol Cell. 2014;25:3037-48 pubmed publisher
Chen S, Zhou H, Byun H, Pan H. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms. J Pharmacol Exp Ther. 2013;347:765-72 pubmed publisher
Santos D, Xavier J, Morgado A, Sola S, Rodrigues C. Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation. PLoS ONE. 2012;7:e33468 pubmed publisher
Leytin V, Allen D, Mutlu A, Gyulkhandanyan A, Mykhaylov S, Freedman J. Mitochondrial control of platelet apoptosis: effect of cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. Lab Invest. 2009;89:374-84 pubmed publisher
Amadoro G, Ciotti M, Costanzi M, Cestari V, Calissano P, Canu N. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci U S A. 2006;103:2892-7 pubmed

product information

brand :

Tocris

master code :

0448

SKU :

0448/10

product name :

Calpeptin

description :

Calpain and cathepsin L inhibitor

target :

Calcium-Sensitive Protease Modulator Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

362.47

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases. Also inhibits SARS-CoV-2 Mpro in vitro (IC50 = 10.7 M) and inhibits viral replication.

catalog number base :

448

product keywords :

Calpain cathepsin L inhibitors inhibits Proteinases Proteases Ca2+Sensitive Protease modulators Calcium-Sensitive Ca2+ Signaling Signalling Calcium-Sensitive Proteases Calpains Cathepsin 3C and 3CL Proteases 0448,

extended description :

Calpain and cathepsin L inhibitor

chemical name text :

N-Benzyloxycarbonyl-L-leucylnorleucinal

formula :

C 20 H 30 N 2 O 4

formula text :

C20H30N2O4

cas num :

117591-20-5

2020 USD :

164

2021 USD :

169 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage