Clozapine | Tocris Bioscience 0444 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Clozapine

catalog :

0444

quantity :

50 mg (also 500 mg)

price :

159 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Joshi R, Panicker M. Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs. Eneuro. 2018;5: pubmed publisher
Peng Y, McCorvy J, Harpsøe K, Lansu K, Yuan S, Popov P, et al. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell. 2018;172:719-730.e14 pubmed publisher
Griebel G, Pichat P, Boulay D, Naimoli V, Potestio L, Featherstone R, et al. The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia. Sci Rep. 2016;6:35320 pubmed publisher
Cui L, Sun W, Yu M, Li N, Guo L, Gu H, et al. Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits. Mol Brain. 2016;9:89 pubmed
CanfrÃ¡n Duque A, Pastor O, Reina M, Lerma M, Cruz Jentoft A, LasunciÃ³n M, et al. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. PLoS ONE. 2015;10:e0141829 pubmed publisher
Larsson M, Schwieler L, Goiny M, Erhardt S, Engberg G. Chronic Antipsychotic Treatment in the Rat - Effects on Brain Interleukin-8 and Kynurenic Acid. Int J Tryptophan Res. 2015;8:49-52 pubmed publisher
Jia J, Zhao J, Hu Z, Lindberg D, Li Z. Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci. 2013;16:1627-36 pubmed publisher
Chau K, Cooper J, Schapira A. Pramipexole reduces phosphorylation of α-synuclein at serine-129. J Mol Neurosci. 2013;51:573-80 pubmed publisher
Kurita M, Holloway T, García Bea A, Kozlenkov A, Friedman A, Moreno J, et al. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 2012;15:1245-54 pubmed publisher
Herwerth M, Jensen V, Novak M, Konopka W, Hvalby O, Köhr G. D4 dopamine receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1. Cereb Cortex. 2012;22:1786-98 pubmed publisher
Hillenmeyer M, Ericson E, Davis R, Nislow C, Koller D, Giaever G. Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action. Genome Biol. 2010;11:R30 pubmed publisher
Oliver P, Davies K. Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. Hum Mol Genet. 2009;18:4576-89 pubmed publisher
Magliaro B, Saldanha C. Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation. Brain Res. 2009;1283:14-24 pubmed publisher
Singh R, Dai Y, Staudinger J, Muma N. Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907. Int J Neuropsychopharmacol. 2009;12:651-65 pubmed publisher
Balu D, Hoshaw B, Malberg J, Rosenzweig Lipson S, Schechter L, Lucki I. Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res. 2008;1211:37-43 pubmed publisher
Roh M, Seo M, Kim Y, Kim S, Jeon W, Ahn Y, et al. Haloperidol and clozapine differentially regulate signals upstream of glycogen synthase kinase 3 in the rat frontal cortex. Exp Mol Med. 2007;39:353-60 pubmed
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed
Sur C, Mallorga P, Wittmann M, Jacobson M, Pascarella D, Williams J, et al. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A. 2003;100:13674-9 pubmed

product information

brand :

Tocris

master code :

0444

SKU :

0444/50

product name :

Clozapine

description :

Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist

target :

Non-selective Dopamine Receptor Antagonists

category :

Small Molecules

unit size :

50 mg (also 500 mg)

purity :

99%

observed molecular weight :

326.83

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki values are 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively).

catalog number base :

444

product keywords :

Dopamine antagonists D4 selectivity 5HT2A/2C Non-Selective Receptors Serotonin 5HT2C 5HT2 5HT2A dopaminergic Non-selective Dopamine 5-HT2A Receptors 5-HT2C Receptors 0444,

extended description :

Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist

chemical name text :

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

formula :

C 18 H 19 ClN 4

formula text :

C18H19ClN4

cas num :

5786-21-0

2020 USD :

152

2021 USD :

159 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage