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company name :
Tocris Bioscience
product type :
chemical
product name :
0439/100
catalog :
0439/100
quantity :
100 mg
price :
251 USD
more info or order :
citations: 48
Reference
Liu G, Zhang W, Guo J, Kong F, Zhou S, Chen S, et al. Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res. 2018;1700:47-55 pubmed publisher
Di Angelantonio S, Bertollini C, Piccinin S, Rosito M, Trettel F, Pagani F, et al. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. Front Cell Neurosci. 2015;9:409 pubmed publisher
Stoddart L, Johnstone E, Wheal A, Goulding J, Robers M, Machleidt T, et al. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015;12:661-663 pubmed publisher
Dobson K, Jackson C, Balakrishnan S, Bellamy T. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. PLoS ONE. 2015;10:e0125974 pubmed publisher
Cunha M, Pazini F, Rosa J, Ramos Hryb A, Oliveira Ã, Kaster M, et al. Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A₁ and A2A receptor activation. Purinergic Signal. 2015;11:215-27 pubmed publisher
Kohno K, Ohashi E, Sano O, Kusano H, Kunikata T, Arai N, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015;12:2 pubmed publisher
Aeffner F, Woods P, Davis I. Activation of A1-adenosine receptors promotes leukocyte recruitment to the lung and attenuates acute lung injury in mice infected with influenza A/WSN/33 (H1N1) virus. J Virol. 2014;88:10214-27 pubmed publisher
Carlsen E, Perrier J. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits. 2014;8:60 pubmed publisher
Li H, Chuang A, O BRIEN J. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci. 2014;31:237-43 pubmed publisher
Ruby C, Vadnie C, Hinton D, Abulseoud O, Walker D, O Connor K, et al. Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light. Neuropsychopharmacology. 2014;39:2432-40 pubmed publisher
Ouyang X, Ghani A, Malik A, Wilder T, COLEGIO O, Flavell R, et al. Adenosine is required for sustained inflammasome activation via the A?A receptor and the HIF-1? pathway. Nat Commun. 2013;4:2909 pubmed publisher
Scianni M, Antonilli L, Chece G, Cristalli G, Di Castro M, Limatola C, et al. Fractalkine (CX3CL1) enhances hippocampal N-methyl-D-aspartate receptor (NMDAR) function via D-serine and adenosine receptor type A2 (A2AR) activity. J Neuroinflammation. 2013;10:108 pubmed publisher
Augusto E, Matos M, Sevigny J, El Tayeb A, Bynoe M, Muller C, et al. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. J Neurosci. 2013;33:11390-9 pubmed publisher
Kaster M, Budni J, Gazal M, Cunha M, Santos A, Rodrigues A. The antidepressant-like effect of inosine in the FST is associated with both adenosine A1 and A 2A receptors. Purinergic Signal. 2013;9:481-6 pubmed publisher
Fuss J, Vogt M, Weber K, Burke T, Gass P, Hensler J. Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running. Synapse. 2013;67:648-55 pubmed publisher
Lee S, Kim J, Kim J, Jang Y, Kim J, Park Y, et al. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study. Korean J Anesthesiol. 2012;63:340-5 pubmed publisher
Stoddart L, Vernall A, Denman J, Briddon S, Kellam B, Hill S. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol. 2012;19:1105-15 pubmed publisher
Diógenes M, Neves Tomé R, Fucile S, Martinello K, Scianni M, Theofilas P, et al. Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex. 2014;24:67-80 pubmed publisher
Kan Y, Okabayashi T, Yokota S, Yamamoto S, Fujii N, Yamashita T. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012;86:10338-46 pubmed publisher
Park S, Kim J, Ham A, Brown K, Kim M, D Agati V, et al. A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2012;303:F721-32 pubmed publisher
Aitta Aho T, Möykkynen T, Panhelainen A, Vekovischeva O, Bäckström P, Korpi E. Importance of GluA1 subunit-containing AMPA glutamate receptors for morphine state-dependency. PLoS ONE. 2012;7:e38325 pubmed publisher
Ilie A, Raimondo J, Akerman C. Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. J Neurosci. 2012;32:5321-32 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Caiati M, Sivakumaran S, Lanore F, Mulle C, Richard E, Verrier D, et al. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep. 2012;2:285 pubmed publisher
Hensler J, Advani T, Burke T, Cheng K, Rice K, Koek W. GABAB receptor-positive modulators: brain region-dependent effects. J Pharmacol Exp Ther. 2012;340:19-26 pubmed publisher
Lutz P, Pradhan A, Goeldner C, Kieffer B. Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine. Eur Neuropsychopharmacol. 2011;21:835-40 pubmed publisher
Mioranzza S, Costa M, Botton P, Ardais A, Matte V, Espinosa J, et al. Blockade of adenosine A(1) receptors prevents methylphenidate-induced impairment of object recognition task in adult mice. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:169-76 pubmed publisher
Sousa V, Assaife Lopes N, Ribeiro J, Pratt J, Brett R, Sebastião A. Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of ?9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology. 2011;36:472-87 pubmed publisher
Burbassi S, Sengupta R, Meucci O. Alterations of CXCR4 function in ?-opioid receptor-deficient glia. Eur J Neurosci. 2010;32:1278-88 pubmed publisher
Long X, Mokelke E, Neeb Z, Alloosh M, Edwards J, Sturek M. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Pharmacol Exp Ther. 2010;335:781-7 pubmed publisher
Thakkar M, Engemann S, Sharma R, Sahota P. Role of wake-promoting basal forebrain and adenosinergic mechanisms in sleep-promoting effects of ethanol. Alcohol Clin Exp Res. 2010;34:997-1005 pubmed publisher
Yang A, Mucsi A, Desrosiers M, Chen J, Schnermann J, Blackburn M, et al. Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J Immunol. 2010;40:449-59 pubmed publisher
Clark B, Kurth Nelson Z, Newman E. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. J Neurosci. 2009;29:11237-45 pubmed publisher
Xi J, McIntosh R, Shen X, Lee S, Chanoit G, Criswell H, et al. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol. 2009;47:684-90 pubmed publisher
Yu E, Traylor Z, Davis I. Effect of ventilation pressure on alveolar fluid clearance and beta-agonist responses in mice. Am J Physiol Lung Cell Mol Physiol. 2009;297:L785-93 pubmed publisher
Rex C, Chen L, Sharma A, Liu J, Babayan A, Gall C, et al. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol. 2009;186:85-97 pubmed publisher
Epperson S, Brunton L, Ramirez Sanchez I, Villarreal F. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2009;296:C1171-7 pubmed publisher
Maeda T, Koos B. Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2009;296:R693-701 pubmed publisher
Eckle T, Grenz A, Laucher S, Eltzschig H. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest. 2008;118:3301-15 pubmed publisher
Wolk K, Lazarowski E, Traylor Z, Yu E, Jewell N, Durbin R, et al. Influenza A virus inhibits alveolar fluid clearance in BALB/c mice. Am J Respir Crit Care Med. 2008;178:969-76 pubmed publisher
Bhanu N, Lee Y, Oneal P, Gantt N, Aerbajinai W, Noel P, et al. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. Biochim Biophys Acta. 2008;1782:504-10 pubmed publisher
Burbassi S, Aloyo V, Simansky K, Meucci O. GTPgammaS incorporation in the rat brain: a study on mu-opioid receptors and CXCR4. J Neuroimmune Pharmacol. 2008;3:26-34 pubmed publisher
Satake S, Song S, Cao Q, Satoh H, Rusakov D, Yanagawa Y, et al. Characterization of AMPA receptors targeted by the climbing fiber transmitter mediating presynaptic inhibition of GABAergic transmission at cerebellar interneuron-Purkinje cell synapses. J Neurosci. 2006;26:2278-89 pubmed
Rex C, Kramar E, Colgin L, Lin B, Gall C, Lynch G. Long-term potentiation is impaired in middle-aged rats: regional specificity and reversal by adenosine receptor antagonists. J Neurosci. 2005;25:5956-66 pubmed
Newman E. Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J Neurosci. 2005;25:5502-10 pubmed
Kornerup K, Page C, Moffatt J. Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. Br J Pharmacol. 2005;144:1011-6 pubmed
Melyan Z, Lancaster B, Wheal H. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci. 2004;24:4530-4 pubmed
Moore K, Nicoll R, Schmitz D. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses. Proc Natl Acad Sci U S A. 2003;100:14397-402 pubmed
product information
master code :
439
SKU :
0439/100
product name :
DPCPX
unit size :
100 mg
description :
Selective A1 antagonist
target :
Adenosine A1 Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
304.39
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
DPCPX is a potent and selective A1 adenosine receptor antagonist, both in vitro and in vivo . Ki values are 3.9, 130, 50 and 4000 nM for human A1, A2A, A2B and A3 receptors respectively.
top caption :
Selective A1 antagonist
extended description :
Selective A1 antagonist
chemical name text :
8-Cyclopentyl-1,3-dipropylxanthine
formula :
C16H24N4O2
formula text :
C16H24N4O2
cas num :
102146-07-6
USD :
251 USD
product details :
Selective A1 antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK