ML 9 hydrochloride | Tocris Bioscience 0431 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 9 hydrochloride

catalog :

0431

quantity :

10 mg (also 50 mg)

price :

161 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Dobson K, Jackson C, Balakrishnan S, Bellamy T. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. PLoS ONE. 2015;10:e0125974 pubmed publisher
Kirschstein T, Protzel C, Porath K, Sellmann T, Köhling R, Hakenberg O. Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro. Acta Pharmacol Sin. 2014;35:74-81 pubmed publisher
Siddoway B, Altimimi H, Hou H, Petralia R, Xu B, Stellwagen D, et al. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci. 2013;33:11206-11 pubmed publisher
Gruszczynska Biegala J, Pomorski P, Wisniewska M, Kuznicki J. Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. PLoS ONE. 2011;6:e19285 pubmed publisher

product information

brand :

Tocris

master code :

0431

SKU :

0431/10

product name :

ML 9 hydrochloride

description :

Myosin light chain kinase inhibitor

target :

Myosin Light Chain Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

361.29

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective MLCK inhibitor (Ki values are 4, 32 and 54 u M for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).

catalog number base :

431

product keywords :

Myosin light chain kinase inhibitors inhibits STIM1-plasma membrane interaction Kinases Ca2+ Binding Protein modulators Calmodulin CaM Calcium Signaling Signalling Store Operated Channels STIM-Orai ML9 hydrochloride MLCK Myosin Light Chain Kinase Calcium Binding Protein Myosin STIM-Orai Channels 0431,

extended description :

Myosin light chain kinase inhibitor

chemical name text :

1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride

formula :

C 15 H 17 ClN 2 O 2 S.HCl

formula text :

C15H17ClN2O2S.HCl

cas num :

105637-50-1

2020 USD :

154

2021 USD :

161 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage