0427/50 | Tocris Bioscience 0427/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0427/50

catalog :

0427/50

quantity :

50 mg

price :

162 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Pedersen M, Pham J, Mancebo H, Inoue A, Asher W, Javitch J. A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol Chem. 2021;:100503 pubmed publisher
Liberante F, Pouryahya T, McMullin M, Zhang S, Mills K. Identification and validation of the dopamine agonist bromocriptine as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia. Oncotarget. 2016;7:6609-19 pubmed publisher
Jia J, Zhao J, Hu Z, Lindberg D, Li Z. Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci. 2013;16:1627-36 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher

product information

master code :

427

SKU :

0427/50

product name :

Bromocriptine mesylate

unit size :

50 mg

description :

D2-like agonist (D2>D3>D4)

target :

Non-selective Dopamine Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

750.7

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Bromocriptine mesylate is a selective D3 and D2 dopamine receptor agonist (Ki values are ~ 5 nM and ~ 8 nM respectively). Activates both isoforms of D2 receptor (EC50 values are 0.10-0.12 nM and 4.4 nM for D2L and D2S receptors, respectively. Bromocriptine shows anti-A effects that are increased in combination with Cromolyn (Cat. No. 6424) and Topiramate (Cat. No. 3620). Also lowers glucose and increases insulin sensitivity in vivo .

top caption :

D2-like agonist (D2>D3>D4)

extended description :

D2-like agonist (D2>D3>D4)

chemical name text :

(5 a)-2-Bromo-12 -hydroxy-2 -(1-methylethyl)-5 -(2-methylpropyl)ergotaman-3 ,6 ,18-trione mesylate

formula :

C32H40BrN5O5.CH3SO3H

formula text :

C32H40BrN5O5.CH3SO3H

cas num :

22260-51-1

USD :

162 USD

product details :

D2-like agonist (D2>D3>D4)

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage