product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
GBR 12909 dihydrochloride
catalog :
0421
quantity :
10 mg (also 50 mg)
price :
93 USD
more info or order :
citations: 12
Reference |
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Beerepoot P, Lam V, Salahpour A. Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells. J Biol Chem. 2016;291:22053-22062 pubmed
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Koprich J, Johnston T, Reyes M, Sun X, Brotchie J. Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model th. Mol Neurodegener. 2010;5:43 pubmed publisher
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Visanji N, Orsi A, Johnston T, Howson P, Dixon K, Callizot N, et al. PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease. FASEB J. 2008;22:2488-97 pubmed publisher
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product information
brand :
Tocris
master code :
0421
SKU :
0421/10
product name :
GBR 12909 dihydrochloride
description :
Selective DA uptake inhibitor; also ligand
target :
Dopamine Transporter Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
523.49
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
catalog number base :
421
product keywords :
Potent sigma ligand DA uptake inhibitors inhibits Selective General Receptors DAT Dopamine Transporters Monoamine Neurotransmitter GBR12909 dihydrochloride Dopamine Transporters Sigma-Related 0421,
extended description :
Selective DA uptake inhibitor; also ligand
chemical name text :
1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
formula :
C 28 H 32 F 2 N 2 O.2HCl
formula text :
C28H32F2N2O.2HCl
cas num :
67469-78-7
2020 USD :
89
2021 USD :
93 USD
storage :
Desiccate at RT
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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