product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
GBR 12909 dihydrochloride
catalog :
0421
quantity :
10 mg (also 50 mg)
price :
93 USD
more info or order :
citations: 12
Reference
Beerepoot P, Lam V, Salahpour A. Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells. J Biol Chem. 2016;291:22053-22062 pubmed
Kim J, Tillu D, Quinn T, Mejia G, Shy A, Asiedu M, et al. Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. J Neurosci. 2015;35:6307-17 pubmed publisher
Squillace M, Dodero L, Federici M, Migliarini S, Errico F, Napolitano F, et al. Dysfunctional dopaminergic neurotransmission in asocial BTBR mice. Transl Psychiatry. 2014;4:e427 pubmed publisher
Wang Y, Lee J, Oh G, Grady S, McIntosh J, Brunzell D, et al. Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function ?6* nAChRs. J Neurochem. 2014;129:315-27 pubmed publisher
Patel A, Zhu Y, Kuzhikandathil E, Banks W, Siegel A, Zalcman S. Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits. PLoS ONE. 2012;7:e41623 pubmed publisher
Navaroli D, Stevens Z, Uzelac Z, Gabriel L, King M, Lifshitz L, et al. The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. J Neurosci. 2011;31:13758-70 pubmed publisher
Hutchinson A, Deng J, Aryal D, Wetsel W, West A. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Neuropsychopharmacology. 2012;37:321-37 pubmed publisher
Koprich J, Johnston T, Huot P, Reyes M, Espinosa M, Brotchie J. Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein. PLoS ONE. 2011;6:e17698 pubmed publisher
Koprich J, Johnston T, Reyes M, Sun X, Brotchie J. Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model th. Mol Neurodegener. 2010;5:43 pubmed publisher
Abdallah L, Bonasera S, Hopf F, O DELL L, Giorgetti M, Jongsma M, et al. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. J Neurosci. 2009;29:8156-65 pubmed publisher
Costa C, Belcastro V, Tozzi A, Di Filippo M, Tantucci M, Siliquini S, et al. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci. 2008;28:8040-52 pubmed publisher
Visanji N, Orsi A, Johnston T, Howson P, Dixon K, Callizot N, et al. PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease. FASEB J. 2008;22:2488-97 pubmed publisher
product information
brand :
Tocris
master code :
0421
SKU :
0421/10
product name :
GBR 12909 dihydrochloride
description :
Selective DA uptake inhibitor; also ligand
target :
Dopamine Transporter Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
523.49
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
catalog number base :
421
product keywords :
Potent sigma ligand DA uptake inhibitors inhibits Selective General Receptors DAT Dopamine Transporters Monoamine Neurotransmitter GBR12909 dihydrochloride Dopamine Transporters Sigma-Related 0421,
extended description :
Selective DA uptake inhibitor; also ligand
chemical name text :
1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
formula :
C 28 H 32 F 2 N 2 O.2HCl
formula text :
C28H32F2N2O.2HCl
cas num :
67469-78-7
2020 USD :
89
2021 USD :
93 USD
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK