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company name :
Tocris Bioscience
product type :
chemical
product name :
0417/1G
catalog :
0417/1G
quantity :
1 g
price :
108 USD
more info or order :
citations: 23
Reference
Limon A, Delbruck E, Yassine A, Pandya D, Myers R, Barchas J, et al. Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors. Transl Psychiatry. 2019;9:218 pubmed publisher
Vergassola M, Olivero G, Cisani F, Usai C, Bossi S, Puliti A, et al. Presynaptic mGlu1 Receptors Control GABAB Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings. Front Mol Neurosci. 2018;11:324 pubmed publisher
Doshina A, Gourgue F, Onizuka M, Opsomer R, Wang P, Ando K, et al. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission. Sci Rep. 2017;7:370 pubmed publisher
Yu J, Swietek B, Proddutur A, Santhakumar V. Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. Neurobiol Dis. 2016;89:23-35 pubmed publisher
Baquero A, Kirigiti M, Baquero K, Lee S, Smith M, Grove K. Developmental changes in synaptic distribution in arcuate nucleus neurons. J Neurosci. 2015;35:8558-69 pubmed publisher
Bell L, Bell K, McQuiston A. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. Front Cell Neurosci. 2015;9:115 pubmed publisher
Rubio F, Liu Q, Li X, Cruz F, Leão R, Warren B, et al. Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. J Neurosci. 2015;35:5625-39 pubmed publisher
Terunuma M, Haydon P, Pangalos M, Moss S. Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. Neuropharmacology. 2015;88:74-81 pubmed publisher
Chen Z, Xiong C, Pancyr C, Stockwell J, Walz W, Cayabyab F. Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential re. J Neurosci. 2014;34:9621-43 pubmed publisher
Zemoura K, Schenkel M, Acuña M, Yevenes G, Zeilhofer H, Benke D. Endoplasmic reticulum-associated degradation controls cell surface expression of ?-aminobutyric acid, type B receptors. J Biol Chem. 2013;288:34897-905 pubmed publisher
Yang S, Chung P, Ho C, Kuo C, Hung M, Huang Y, et al. Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1. J Immunol. 2013;190:6511-9 pubmed publisher
van Kerkhof L, Damsteegt R, Trezza V, Voorn P, Vanderschuren L. Social play behavior in adolescent rats is mediated by functional activity in medial prefrontal cortex and striatum. Neuropsychopharmacology. 2013;38:1899-909 pubmed publisher
Wojnicki F, Charny G, Corwin R. Baclofen-induced reductions in optional food intake depend upon food composition. Appetite. 2013;64:62-70 pubmed publisher
Baloucoune G, Chun L, Zhang W, Xu C, Huang S, Sun Q, et al. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS ONE. 2012;7:e39698 pubmed publisher
Won Y, Ono F, Ikeda S. Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons. J Neurophysiol. 2011;105:442-53 pubmed publisher
Olmos Serrano J, Paluszkiewicz S, Martin B, Kaufmann W, Corbin J, Huntsman M. Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. J Neurosci. 2010;30:9929-38 pubmed publisher
Takesian A, Kotak V, Sanes D. Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity. J Neurosci. 2010;30:2716-27 pubmed publisher
Tu H, Xu C, Zhang W, Liu Q, Rondard P, Pin J, et al. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci. 2010;30:749-59 pubmed publisher
Bray J, Mynlieff M. Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus. Dev Neurobiol. 2009;69:885-96; erratum 897-912 pubmed publisher
Petzold G, Albeanu D, Sato T, Murthy V. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. Neuron. 2008;58:897-910 pubmed publisher
Maher B, Westbrook G. Co-transmission of dopamine and GABA in periglomerular cells. J Neurophysiol. 2008;99:1559-64 pubmed publisher
Miyazato M, Sasatomi K, Hiragata S, Sugaya K, Chancellor M, de Groat W, et al. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. J Urol. 2008;179:1178-83 pubmed publisher
Jakubs K, Nanobashvili A, Bonde S, Ekdahl C, Kokaia Z, Kokaia M, et al. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron. 2006;52:1047-59 pubmed
product information
master code :
417
SKU :
0417/1G
product name :
(RS)-Baclofen
unit size :
1 g
description :
Selective GABAB agonist
target :
GABA-B Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
213.66
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( RS )-Baclofen is a selective GABAB receptor agonist. Skeletal muscle relaxant. . R-enantiomer also available.
top caption :
Selective GABAB agonist
extended description :
Selective GABAB agonist
chemical name text :
(RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
formula :
C10H12ClNO2
formula text :
C10H12ClNO2
cas num :
1134-47-0
USD :
108 USD
product details :
Selective GABAB agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK