product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0414/10
catalog :
0414/10
quantity :
10 mg (also 50 mg)
price :
157 USD
more info or order :
citations: 17
Reference |
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Qin K, Chen K, Zhao W, Zhao X, Luo J, Wang Q, et al. Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway. J Immunol Res. 2018;2018:3619320 pubmed publisher
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Gross E, Hsu A, Gross G. The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol. 2006;291:H827-34 pubmed
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Bellik L, Vinci M, Filippi S, Ledda F, Parenti A. Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia. Br J Pharmacol. 2005;146:568-75 pubmed
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product information
master code :
414
SKU :
0414/10
product name :
AG 490
unit size :
10 mg (also 50 mg)
description :
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
target :
EGF Receptor Inhibitors
category :
Small Molecules
purity :
99%
observed molecular weight :
294.31
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 u M for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo .
top caption :
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
extended description :
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
chemical name text :
(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
formula :
C17H14N2O3
formula text :
C17H14N2O3
cas num :
133550-30-8
USD :
157 USD
product details :
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
alt names :
Tyrphostin AG 490
storage :
Store at RT
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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