0379/10 | Tocris Bioscience 0379/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0379/10

catalog :

0379/10

quantity :

10 mg

price :

243 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Ki Y, Lim C. Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive. elife. 2019;8: pubmed publisher
Martelli C, Fiala A. Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila. elife. 2019;8: pubmed publisher
Lecat Guillet N, Monnier C, Rovira X, Kniazeff J, Lamarque L, Zwier J, et al. FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor. Cell Chem Biol. 2017;24:360-370 pubmed publisher
Ignell R, Root C, Birse R, Wang J, Nassel D, Winther A. Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila. Proc Natl Acad Sci U S A. 2009;106:13070-5 pubmed publisher
Chen T, Cheng Y, Sun W, Shyu B. Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice. Mol Pain. 2008;4:41 pubmed publisher
Root C, Masuyama K, Green D, Enell L, Nassel D, Lee C, et al. A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron. 2008;59:311-21 pubmed publisher
Piqueras L, Martinez V. Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol. 2004;142:1038-48 pubmed
Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed

product information

master code :

379

SKU :

0379/10

product name :

SKF 97541

unit size :

10 mg

description :

Highly potent GABAB agonist; also GABAA- antagonist

target :

GABA-B Receptor Agonists

category :

Small Molecules

observed molecular weight :

137.12

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SKF 97541 is a potent GABAB agonist (EC50 = 50 nM). SKF 97541 depresses striatal synaptic potentials and hyperpolarizes nigral neurons (EC50 values = 92 nM and 150 nM, respectively). SKF 97541 shows antidepressant effects in animal models and is also a GABAA- antagonist.

top caption :

Highly potent GABAB agonist; also GABAA- antagonist

extended description :

Highly potent GABAB agonist; also GABAA- antagonist

chemical name text :

3-Aminopropyl(methyl)phosphinic acid

formula :

C4H12NO2P

formula text :

C4H12NO2P

cas num :

127729-35-5

USD :

243 USD

product details :

Highly potent GABAB agonist; also GABAA- antagonist

alt names :

CGP 35024

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage