product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0369/100
catalog :
0369/100
quantity :
100 mg
price :
191 USD
more info or order :
citations: 16
Reference
Lopez J, L xfc cken M, Brivio E, Karamihalev S, Kos A, De Donno C, et al. Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron. 2022;110:2283-2298.e9 pubmed publisher
Schiff L, Boles N, Fernandes M, Nachmani B, Gentile R, Blenkinsop T. P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy. Commun Biol. 2019;2:162 pubmed publisher
Haag N, Schüler S, Nietzsche S, Hübner C, Strenzke N, Qualmann B, et al. The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep. 2018;24:2418-2431.e6 pubmed publisher
Yanda M, Liu Q, Cebotaru V, Guggino W, Cebotaru L. Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease. J Biol Chem. 2017;292:17897-17908 pubmed publisher
Gray M, Golowasch J. Voltage Dependence of a Neuromodulator-Activated Ionic Current. Eneuro. 2016;3: pubmed publisher
Hou W, Izadi M, Nemitz S, Haag N, Kessels M, Qualmann B. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. PLoS Biol. 2015;13:e1002233 pubmed publisher
Yuan G, Vasavda C, Peng Y, Makarenko V, Raghuraman G, Nanduri J, et al. Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal. 2015;8:ra37 pubmed publisher
Bonnefond M, Lambert B, Giffard F, Abeilard E, Brotin E, Louis M, et al. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Apoptosis. 2015;20:535-50 pubmed publisher
Araki Y, Zeng M, Zhang M, Huganir R. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. Neuron. 2015;85:173-89 pubmed publisher
Mukunda L, Lavista Llanos S, Hansson B, Wicher D. Dimerisation of the Drosophila odorant coreceptor Orco. Front Cell Neurosci. 2014;8:261 pubmed publisher
Chang M, Lin L, Wu H, Ho Y, Hsien H, Wang T, et al. Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. Carcinogenesis. 2013;34:1096-104 pubmed publisher
Abdou H, Villeneuve G, Tremblay J. The calcium signaling pathway regulates leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein. Endocrinology. 2013;154:511-20 pubmed publisher
Midkiff J, Borochoff Porte N, White D, Johnson D. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS ONE. 2011;6:e25395 pubmed publisher
Dai Y, Dudek N, Li Q, Muma N. Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase. Psychopharmacology (Berl). 2011;213:403-12 pubmed publisher
Yanes L, Romero D. Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells. Mol Cell Endocrinol. 2009;303:50-6 pubmed publisher
Long P, Mercer A, Begum R, Stephens G, Sihra T, Jovanovic J. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. J Biol Chem. 2009;284:8726-37 pubmed publisher
product information
master code :
369
SKU :
0369/100
product name :
W-7 hydrochloride
unit size :
100 mg
description :
Calmodulin antagonist. Inhibits myosin light chain kinase
target :
Calcium Binding Protein Modulator Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
377.33
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
W-7 hydrochloride is a calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 M) and myosin light chain kinase (IC50 = 51 M). Induces shedding of platelet receptors GPVI, GPV and GPIb .
top caption :
Calmodulin antagonist. Inhibits myosin light chain kinase
extended description :
Calmodulin antagonist. Inhibits myosin light chain kinase
chemical name text :
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
formula :
C16H21ClN2O2S.HCl
formula text :
C16H21ClN2O2S.HCl
cas num :
61714-27-0
USD :
191 USD
product details :
Calmodulin antagonist. Inhibits myosin light chain kinase
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK