product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
nor-Binaltorphimine dihydrochloride
catalog :
0347
quantity :
10 mg (also 50 mg)
price :
167 USD
more info or order :
citations: 29
Reference
Pina M, Pati D, Hwa L, Wu S, Mahoney A, Omenyi C, et al. The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrainprojections from the insular cortex. Neuropharmacology. 2020;165:107831 pubmed publisher
Norris C, Szkudlarek H, Pereira B, Rushlow W, Laviolette S. The Bivalent Rewarding and Aversive properties of Δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions. Sci Rep. 2019;9:9760 pubmed publisher
Dai W, Liu X, Bao Y, Yan B, Jiang N, Yu B, et al. Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner. Exp Mol Med. 2018;50:148 pubmed publisher
Polter A, Barcomb K, Chen R, Dingess P, Graziane N, Brown T, et al. Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress. elife. 2017;6: pubmed publisher
Smith C, Walker L, Leeboonngam T, McKinley M, Denton D, Lawrence A. Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice. Proc Natl Acad Sci U S A. 2016;113:13893-13898 pubmed
Chen C, Lu M, Pan Q, Fichna J, Zheng L, Wang K, et al. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. PLoS ONE. 2015;10:e0145556 pubmed publisher
Yi P, Lu C, Jou S, Chang F. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. J Biomed Sci. 2015;22:49 pubmed publisher
Lee H, Ko M. Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Sci Rep. 2015;5:11676 pubmed publisher
Chen X, Wang T, Lin C, Chen B. Effect of adenoviral delivery of prodynorphin gene on experimental inflammatory pain induced by formalin in rats. Int J Clin Exp Med. 2014;7:4877-86 pubmed
Ruiz Pino F, Garcia Galiano D, Manfredi Lozano M, Leon S, Sánchez Garrido M, Roa J, et al. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology. 2015;156:576-88 pubmed publisher
Ma J, Wan J, Meng J, Banerjee S, Ramakrishnan S, Roy S. Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor. Cell Death Dis. 2014;5:e1099 pubmed publisher
Kuzmin A, Chefer V, Bazov I, Meis J, Ogren S, Shippenberg T, et al. Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment. Transl Psychiatry. 2013;3:e310 pubmed publisher
Schmid C, Streicher J, Groer C, Munro T, Zhou L, Bohn L. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons. J Biol Chem. 2013;288:22387-98 pubmed publisher
Tejeda H, Counotte D, Oh E, Ramamoorthy S, Schultz Kuszak K, Bäckman C, et al. Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion. Neuropsychopharmacology. 2013;38:1770-9 pubmed publisher
Morse M, Sun H, Tran E, Levenson R, Fang Y. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol. 2013;14:17 pubmed publisher
Romero Picó A, Vazquez M, González Touceda D, Folgueira C, Skibicka K, Alvarez Crespo M, et al. Hypothalamic ?-opioid receptor modulates the orexigenic effect of ghrelin. Neuropsychopharmacology. 2013;38:1296-307 pubmed publisher
Rogala B, Li Y, Li S, Chen X, Kirouac G. Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats. PLoS ONE. 2012;7:e49669 pubmed publisher
Grachev P, Li X, Lin Y, Hu M, Elsamani L, Paterson S, et al. GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. PLoS ONE. 2012;7:e44344 pubmed publisher
Guida F, Luongo L, Aviello G, Palazzo E, De Chiaro M, Gatta L, et al. Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. Mol Pain. 2012;8:60 pubmed publisher
Kuzumaki N, Suzuki A, Hosoya T, Nagasawa A, Imai S, Yamamizu K, et al. Effect of ?-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells. Br J Cancer. 2012;106:1148-52 pubmed publisher
Morse M, Tran E, Sun H, Levenson R, Fang Y. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS ONE. 2011;6:e25643 pubmed publisher
Russell Randall K, Dortch Carnes J. Kappa opioid receptor localization and coupling to nitric oxide production in cells of the anterior chamber. Invest Ophthalmol Vis Sci. 2011;52:5233-9 pubmed publisher
Jones D, Hallyburton I, Stojanovski L, Read K, Frearson J, Fairlamb A. Identification of a ?-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 2010;80:1478-86 pubmed publisher
Gross G, Baker J, Hsu A, Wu H, Falck J, Nithipatikom K. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. Am J Physiol Heart Circ Physiol. 2010;298:H2201-7 pubmed publisher
Carr G, Bangasser D, Bethea T, Young M, Valentino R, Lucki I. Antidepressant-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats. Neuropsychopharmacology. 2010;35:752-63 pubmed publisher
Cheng C, Yi P, Lin J, Chang F. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats. Evid Based Complement Alternat Med. 2011;2011:159209 pubmed publisher
Braida D, Capurro V, Zani A, Rubino T, Vigano D, Parolaro D, et al. Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents. Br J Pharmacol. 2009;157:844-53 pubmed publisher
Land B, Bruchas M, Lemos J, Xu M, Melief E, Chavkin C. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci. 2008;28:407-14 pubmed publisher
García Fuster M, Miralles A, Garcia Sevilla J. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. Neuropsychopharmacology. 2007;32:399-411 pubmed
product information
brand :
Tocris
master code :
0347
SKU :
0347/10
product name :
nor-Binaltorphimine dihydrochloride
description :
Selective antagonist
target :
Kappa Opioid Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
734.72
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
A selective -opioid receptor antagonist.
catalog number base :
347
product keywords :
selective antagonists -opioid kappa-opioid KOP Receptors OP2 nor-BNI Norbinaltorphimine Kappa Opioid Receptors 0347,
extended description :
Selective antagonist
chemical name text :
17,17 -(Dicyclopropylmethyl)-6,6 ,7,7 -6,6 -imino- 7,7 -binorphinan-3,4 ,14,14 -tetrol dihydrochloride
formula :
C 40 H 43 N 3 O 6 .2HCl
formula text :
C40H43N3O6.2HCl
cas num :
113158-34-2
2020 USD :
163
2021 USD :
167 USD
alt names :
nor -BNI, Norbinaltorphimine
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK