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company name :
Tocris Bioscience
product type :
chemical
product name :
0342/1
catalog :
0342/1
quantity :
1 mg (also 10 mg, 50 mg)
price :
97 USD
more info or order :
citations: 74
Reference
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Guo W, Molinaro G, Collins K, Hays S, Paylor R, Worley P, et al. Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice. J Neurosci. 2016;36:2131-47 pubmed publisher
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Zhong P, Liu Y, Hu Y, Wang T, Zhao Y, Liu Q. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. J Neurosci. 2015;35:4469-81 pubmed publisher
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Choi C, Schoenfeld B, Weisz E, Bell A, Chambers D, Hinchey J, et al. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome. J Neurosci. 2015;35:396-408 pubmed publisher
Schmidt H, Kimmey B, Arreola A, Pierce R. Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking. Addict Biol. 2015;20:285-96 pubmed publisher
Ady V, Perroy J, Tricoire L, Piochon C, Dadak S, Chen X, et al. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors. EMBO Rep. 2014;15:103-9 pubmed publisher
Lee H, Lee E, Song Y, Kim E. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130158 pubmed publisher
Sherkhane P, Kapfhammer J. The plasma membrane Ca2+-ATPase2 (PMCA2) is involved in the regulation of Purkinje cell dendritic growth in cerebellar organotypic slice cultures. Neural Plast. 2013;2013:321685 pubmed publisher
Takano T, He W, Han X, Wang F, Xu Q, Wang X, et al. Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices. Glia. 2014;62:78-95 pubmed publisher
Sakuragi S, Tominaga Yoshino K, Ogura A. Involvement of TrkB- and p75(NTR)-signaling pathways in two contrasting forms of long-lasting synaptic plasticity. Sci Rep. 2013;3:3185 pubmed publisher
Ramiro Cortés Y, Israely I. Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression. PLoS ONE. 2013;8:e71155 pubmed publisher
Chen Y, Shen C. Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by microRNA miR-146a-5p. J Neurosci. 2013;33:9013-20 pubmed publisher
Xu W, Tse Y, Dobie F, Baudry M, Craig A, Wong T, et al. Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression. J Neurosci. 2013;33:5867-5877 pubmed publisher
De Pasquale R, Sherman S. A modulatory effect of the feedback from higher visual areas to V1 in the mouse. J Neurophysiol. 2013;109:2618-31 pubmed publisher
Oh W, Hill T, Zito K. Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening. Proc Natl Acad Sci U S A. 2013;110:E305-12 pubmed publisher
Iliff A, Renoux A, Krans A, Usdin K, Sutton M, Todd P. Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice. Hum Mol Genet. 2013;22:1180-92 pubmed publisher
Rojas A, Wetherington J, Shaw R, Serrano G, Swanger S, Dingledine R. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol. 2013;83:106-21 pubmed publisher
Crock L, Kolber B, Morgan C, Sadler K, Vogt S, Bruchas M, et al. Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain. J Neurosci. 2012;32:14217-26 pubmed publisher
Zhong X, Li H, Chang Q. MeCP2 phosphorylation is required for modulating synaptic scaling through mGluR5. J Neurosci. 2012;32:12841-7 pubmed publisher
Wang H, Morishita Y, Miura D, Naranjo J, Kida S, Zhuo M. Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex. Mol Brain. 2012;5:27 pubmed publisher
Kapfhammer J, Gugger O. The analysis of purkinje cell dendritic morphology in organotypic slice cultures. J Vis Exp. 2012;: pubmed publisher
Sun L, Gu L, Wang S, Yuan J, Yang H, Zhu J, et al. N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. PLoS ONE. 2012;7:e32503 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Hays S, Huber K, Gibson J. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry. J Neurosci. 2011;31:14223-34 pubmed publisher
Chen M, Wan Y, ADE K, Ting J, Feng G, Calakos N. Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. J Neurosci. 2011;31:9563-73 pubmed publisher
Bateup H, Takasaki K, Saulnier J, Denefrio C, Sabatini B. Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function. J Neurosci. 2011;31:8862-9 pubmed publisher
Coulon P, Kanyshkova T, Broicher T, Munsch T, Wettschureck N, Seidenbecher T, et al. Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. Front Cell Neurosci. 2010;4:132 pubmed publisher
Thompson J, Perkel D. Endocannabinoids mediate synaptic plasticity at glutamatergic synapses on spiny neurons within a basal ganglia nucleus necessary for song learning. J Neurophysiol. 2011;105:1159-69 pubmed publisher
Citri A, Bhattacharyya S, Ma C, Morishita W, Fang S, Rizo J, et al. Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. J Neurosci. 2010;30:16437-52 pubmed publisher
Schapitz I, Behrend B, Pechmann Y, Lappe Siefke C, Kneussel S, Wallace K, et al. Neuroligin 1 is dynamically exchanged at postsynaptic sites. J Neurosci. 2010;30:12733-44 pubmed publisher
Kolber B, Montana M, Carrasquillo Y, Xu J, Heinemann S, Muglia L, et al. Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J Neurosci. 2010;30:8203-13 pubmed publisher
Kim S, Fraser P, Westaway D, St George Hyslop P, Ehrlich M, Gandy S. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals. J Neurosci. 2010;30:3870-5 pubmed publisher
Hoffman A, Laaris N, Kawamura M, Masino S, Lupica C. Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors. J Neurosci. 2010;30:545-55 pubmed publisher
Citri A, Soler Llavina G, Bhattacharyya S, Malenka R. N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system. Eur J Neurosci. 2009;30:1443-50 pubmed publisher
Glitsch M. Activation of native TRPC3 cation channels by phospholipase D. FASEB J. 2010;24:318-25 pubmed publisher
Bagayogo I, Dreyfus C. Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway. ASN Neuro. 2009;1: pubmed publisher
Patel J, Witkovsky P, Avshalumov M, Rice M. Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release. J Neurosci. 2009;29:6568-79 pubmed publisher
Wang Y, Zheng F, Zhou X, Sun Z, Wang H. Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription. Neurosci Lett. 2009;460:36-40 pubmed publisher
Zhang Y, Venkitaramani D, Gladding C, Zhang Y, Kurup P, Molnar E, et al. The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation. J Neurosci. 2008;28:10561-6 pubmed publisher
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Brager D, Johnston D. Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons. J Neurosci. 2007;27:13926-37 pubmed
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Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology. 2008;54:68-78 pubmed
Li C, Li X, Chen W, Yu S, Chen J, Wang H, et al. The different roles of cyclinD1-CDK4 in STP and mGluR-LTD during the postnatal development in mice hippocampus area CA1. BMC Dev Biol. 2007;7:57 pubmed
Muddashetty R, Kelic S, Gross C, Xu M, Bassell G. Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome. J Neurosci. 2007;27:5338-48 pubmed
Ziskin J, Nishiyama A, Rubio M, Fukaya M, Bergles D. Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci. 2007;10:321-30 pubmed
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Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, et al. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 2006;52:831-43 pubmed
Van Keuren Jensen K, Cline H. Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by homer1a induction. J Neurosci. 2006;26:7575-80 pubmed
Rancillac A, Rossier J, Guille M, Tong X, Geoffroy H, Amatore C, et al. Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. J Neurosci. 2006;26:6997-7006 pubmed
Jiang Q, Yan Z, Feng J. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci. 2006;26:4318-28 pubmed
Etkin A, Alarcon J, Weisberg S, Touzani K, Huang Y, Nordheim A, et al. A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron. 2006;50:127-43 pubmed
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Nishi A, Liu F, Matsuyama S, Hamada M, Higashi H, Nairn A, et al. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Proc Natl Acad Sci U S A. 2003;100:1322-7 pubmed
Huber K, Gallagher S, Warren S, Bear M. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci U S A. 2002;99:7746-50 pubmed
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Job C, Eberwine J. Identification of sites for exponential translation in living dendrites. Proc Natl Acad Sci U S A. 2001;98:13037-42 pubmed
product information
master code :
342
SKU :
0342/1
product name :
(RS)-3,5-DHPG
unit size :
1 mg (also 10 mg, 50 mg)
description :
Selective group I mGlu agonist
target :
Group I mGluR Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
183.16
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( RS )-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5. Also reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D. . S-enantiomer also available.
top caption :
Selective group I mGlu agonist
extended description :
Selective group I mGlu agonist
chemical name text :
(RS)-3,5-Dihydroxyphenylglycine
formula :
C8H9NO4
formula text :
C8H9NO4
cas num :
146255-66-5
USD :
97 USD
product details :
Selective group I mGlu agonist
storage :
Desiccate at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK