product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
(S)-4-Carboxyphenylglycine
catalog :
0323
quantity :
10 mg (also 50 mg)
price :
303 USD
more info or order :
citations: 7
Reference
Riz I, Hawley T, Marsal J, Hawley R. Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming. Oncotarget. 2016;7:66360-66385 pubmed publisher
Griffin W, Ramachandra V, Knackstedt L, Becker H. Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. Front Pharmacol. 2015;6:27 pubmed publisher
Resch J, Albano R, Liu X, Hjelmhaug J, Lobner D, Baker D, et al. Augmented cystine-glutamate exchange by pituitary adenylate cyclase-activating polypeptide signaling via the VPAC1 receptor. Synapse. 2014;68:604-612 pubmed publisher
Overocker J, Pfau J. Cytokine Production Modified by System X(c)- After PM10 and Asbestos Exposure. J Young Investig. 2012;23:34-39 pubmed
Mahler S, Hensley Simon M, Tahsili Fahadan P, Lalumiere R, Thomas C, Fallon R, et al. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addict Biol. 2014;19:49-60 pubmed publisher
Liu R, Blower P, Pham A, Fang J, Dai Z, Wise C, et al. Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Mol Pharmacol. 2007;72:1637-46 pubmed
Porter R, Jaeschke G, Spooren W, Ballard T, Büttelmann B, Kolczewski S, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005;315:711-21 pubmed
product information
brand :
Tocris
master code :
0323
SKU :
0323/10
product name :
(S)-4-Carboxyphenylglycine
description :
Competitive group I mGlu antagonist; also weak group II agonist
target :
Group I mGluR Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
195.17
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Competitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu1a/1a over mGlu5a/5b. . Racemate and R-enantiomer also available.
catalog number base :
323
product keywords :
competitive Group I mGlur antagonists weak group II agonists Competitive Receptors mGlu2 mGlu3 mGluR2 mGluR3 Glutamate Metabotropic mGlu1 mGlu5 mGluR1 mGluR5 (S)-4CPG Glutamate (Metabotropic) Group I Receptors Glutamate (Metabotropic) Group II Receptors 0323,
extended description :
Competitive group I mGlu antagonist; also weak group II agonist
formula :
C 9 H 9 NO 4
formula text :
C9H9NO4
cas num :
134052-73-6
2020 USD :
291
2021 USD :
303 USD
alt names :
( S )-4CPG
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK