0298/10 | Tocris Bioscience 0298/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0298/10

catalog :

0298/10

quantity :

10 mg (also 50 mg)

price :

213 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Heinrich A, Andó R, Turi G, Rozsa B, Sperlagh B. K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol. 2012;167:1003-20 pubmed publisher
Yin H, Weiss J. Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res. 2012;1448:153-62 pubmed publisher
Beaule C, Swanstrom A, Leone M, Herzog E. Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes. PLoS ONE. 2009;4:e7476 pubmed publisher
Young K, McGehee D, Brorson J. Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. Neurobiol Dis. 2007;26:78-85 pubmed

product information

master code :

298

SKU :

0298/10

product name :

L-trans-2,4-PDC

unit size :

10 mg (also 50 mg)

description :

Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor

target :

Glutamate (EAAT) Transporter Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

159.14

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L- trans -2,4-PDC is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. In [3H]-d-Asp uptake assays in HEK293 cells expressing human EAAT1, EAAT2 and EAAT3, Ki values are 20, 20 and 109 M, respectively. In a FLIPR Membrane Potential (FMP) assay, Km values for L- trans -2,4-PDC are 7.7, 11 and 19 M for human EAAT2, EAAT3 and EAAT1, respectively.

top caption :

Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor

extended description :

Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor

chemical name text :

L-trans-Pyrrolidine-2,4-dicarboxylic acid

formula :

C6H9NO4

formula text :

C6H9NO4

cas num :

64769-66-0

USD :

213 USD

product details :

Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor

alt names :

trans -4-Carboxy- L -proline

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage