5,7-Dichlorokynurenic acid | Tocris Bioscience 0286 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5,7-Dichlorokynurenic acid

catalog :

0286

quantity :

10 mg (also 50 mg)

price :

103 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Adamsky A, Kol A, Kreisel T, Doron A, Ozeri Engelhard N, Melcer T, et al. Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement. Cell. 2018;174:59-71.e14 pubmed publisher
Astorga G, Bao J, Marty A, Augustine G, Franconville R, Jalil A, et al. An excitatory GABA loop operating in vivo. Front Cell Neurosci. 2015;9:275 pubmed publisher
Stevens E, Gustafson E, Sullivan S, Esguerra M, Miller R. Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina. Neuroreport. 2010;21:239-44 pubmed publisher
Kenny A, Cousins S, Pinho L, Stephenson F. The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem. 2009;284:324-33 pubmed publisher

product information

brand :

Tocris

master code :

0286

SKU :

0286/10

product name :

5,7-Dichlorokynurenic acid

description :

Potent NMDA antagonist; acts at glycine site

target :

NMDA Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

258.06

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine). . Sodium Salt also available .

catalog number base :

286

product keywords :

Potent NMDA antagonists glycine site Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic NMDA Receptors 0286,

extended description :

Potent NMDA antagonist; acts at glycine site

chemical name text :

5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid

formula :

C 10 H 5 Cl 2 NO 3

formula text :

C10H5Cl2NO3

cas num :

131123-76-7

2020 USD :

2021 USD :

103 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage