product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
0286/10
catalog :
0286/10
quantity :
10 mg (also 50 mg)
price :
131 USD
more info or order :
citations: 5
Reference
Adamsky A, Kol A, Kreisel T, Doron A, Ozeri Engelhard N, Melcer T, et al. Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement. Cell. 2018;174:59-71.e14 pubmed publisher
Astorga G, Bao J, Marty A, Augustine G, Franconville R, Jalil A, et al. An excitatory GABA loop operating in vivo. Front Cell Neurosci. 2015;9:275 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Stevens E, Gustafson E, Sullivan S, Esguerra M, Miller R. Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina. Neuroreport. 2010;21:239-44 pubmed publisher
Kenny A, Cousins S, Pinho L, Stephenson F. The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem. 2009;284:324-33 pubmed publisher
product information
master code :
286
SKU :
0286/10
product name :
5,7-Dichlorokynurenic acid
unit size :
10 mg (also 50 mg)
description :
Potent NMDA antagonist; acts at glycine site
target :
NMDA Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
258.06
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
5,7-Dichlorokynurenic acid is a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine). . Sodium Salt also available .
top caption :
Potent NMDA antagonist; acts at glycine site
extended description :
Potent NMDA antagonist; acts at glycine site
chemical name text :
5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
formula :
C10H5Cl2NO3
formula text :
C10H5Cl2NO3
cas num :
131123-76-7
USD :
131 USD
product details :
Potent NMDA antagonist; acts at glycine site
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK