0247/10 | Tocris Bioscience 0247/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0247/10

catalog :

0247/10

quantity :

10 mg (also 50 mg)

price :

481 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Throesch B, Bin Imtiaz M, Mu xf1 oz Casta xf1 eda R, Sakurai M, Hartzell A, James K, et al. Functional sensory circuits built from neurons of two species. Cell. 2024;187:2143-2157.e15 pubmed publisher
Fan L, Nehme R, Adam Y, Jung E, Wu H, Eggan K, et al. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods. 2018;15:823-831 pubmed publisher
Maeder C, Kim J, Liang X, Kaganovsky K, Shen A, Li Q, et al. The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell. 2018;174:1436-1449.e20 pubmed publisher
Sancho L, Bloodgood B. Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex. Cell Rep. 2018;24:2075-2087 pubmed publisher
Zhang P, Lu H, Peixoto R, Pines M, Ge Y, Oku S, et al. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell. 2018;174:1450-1464.e23 pubmed publisher
Chang J, Higley M. Potassium channels contribute to activity-dependent regulation of dendritic inhibition. Physiol Rep. 2018;6:e13747 pubmed publisher
Collins D, Anastasiades P, Marlin J, Carter A. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron. 2018;98:366-379.e4 pubmed publisher
Chaffiol A, Caplette R, Jaillard C, Brazhnikova E, Desrosiers M, Dubus E, et al. A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina. Mol Ther. 2017;25:2546-2560 pubmed publisher
Pan M, Kuo S, Tai C, Liou J, Pei J, Chang C, et al. Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control. J Clin Invest. 2016;126:4516-4526 pubmed publisher
Tsutsui Kimura I, Yoshida T, Ohmura Y, Izumi T, Yoshioka M. Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
Stephany C, Chan L, Parivash S, Dorton H, Piechowicz M, Qiu S, et al. Plasticity of binocularity and visual acuity are differentially limited by nogo receptor. J Neurosci. 2014;34:11631-40 pubmed publisher
Higley M, Gittis A, Oldenburg I, Balthasar N, Seal R, Edwards R, et al. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS ONE. 2011;6:e19155 pubmed publisher
Wood L, Gray N, Zhou Z, Greenberg M, Shepherd G. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. J Neurosci. 2009;29:12440-8 pubmed publisher
Mao T, O Connor D, Scheuss V, Nakai J, Svoboda K. Characterization and subcellular targeting of GCaMP-type genetically-encoded calcium indicators. PLoS ONE. 2008;3:e1796 pubmed publisher
Vigot R, Barbieri S, Brauner Osborne H, Turecek R, Shigemoto R, Zhang Y, et al. Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 2006;50:589-601 pubmed

product information

master code :

247

SKU :

0247/10

product name :

(R)-CPP

unit size :

10 mg (also 50 mg)

description :

Potent NMDA antagonist; more active enantiomer of (RS)-CPP

target :

NMDA Receptor Antagonists

category :

Small Molecules

observed molecular weight :

252.21

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( R )-CPP is a highly potent NMDA antagonist; more active isomer. Shows some selectivity for GluN2A (formally NR2A) containing receptors (Ki values are 0.041, 0.27, 0.63 and 1.99 u M for inhibition of GluN2A-, GluN2B-, GluN2C- and GluN2D-containing recombinant NMDA receptors respectively). . Racemate also available. . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

top caption :

Potent NMDA antagonist; more active enantiomer of (RS)-CPP

extended description :

Potent NMDA antagonist; more active enantiomer of (RS)-CPP

chemical name text :

3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid

formula :

C8H17N2O5P

formula text :

C8H17N2O5P

cas num :

126453-07-4

USD :

481 USD

product details :

Potent NMDA antagonist; more active enantiomer of (RS)-CPP

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage