product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Saclofen
catalog :
0246
quantity :
10 mg (also 50 mg)
price :
216 USD
more info or order :
citations: 10
Reference
Harte Hargrove L, Varga Wesson A, Duffy A, Milner T, Scharfman H. Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat. J Neurosci. 2015;35:1723-38 pubmed publisher
Atasoy D, Betley J, Li W, Su H, Sertel S, Scheffer L, et al. A genetically specified connectomics approach applied to long-range feeding regulatory circuits. Nat Neurosci. 2014;17:1830-9 pubmed publisher
Atasoy D, Betley J, Su H, Sternson S. Deconstruction of a neural circuit for hunger. Nature. 2012;488:172-7 pubmed publisher
Kramar E, Chen L, Brandon N, Rex C, Liu F, Gall C, et al. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 2009;29:12982-93 pubmed publisher
Miyazato M, Sasatomi K, Hiragata S, Sugaya K, Chancellor M, de Groat W, et al. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. J Urol. 2008;179:1178-83 pubmed publisher
Ying S, Goldstein P. Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. Mol Pain. 2005;1:2 pubmed
Ohba S, Ikeda T, Ikegaya Y, Nishiyama N, Matsuki N, Yamada M. BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Cereb Cortex. 2005;15:291-8 pubmed
Melyan Z, Lancaster B, Wheal H. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci. 2004;24:4530-4 pubmed
Piet R, Vargova L, Sykova E, Poulain D, Oliet S. Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Proc Natl Acad Sci U S A. 2004;101:2151-5 pubmed
Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed
product information
brand :
Tocris
master code :
0246
SKU :
0246/10
product name :
Saclofen
description :
Selective GABAB antagonist
target :
GABA-B Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
249.72
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective antagonist at GABAB receptors.
catalog number base :
246
product keywords :
Selective GABAB antagonists Receptors GABAB Receptors 0246,
extended description :
Selective GABAB antagonist
chemical name text :
(RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
formula :
C 9 H 12 ClNO 3 S
formula text :
C9H12ClNO3S
cas num :
125464-42-8
2020 USD :
207
2021 USD :
216 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK