product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
0246/10
catalog :
0246/10
quantity :
10 mg (also 50 mg)
price :
271 USD
more info or order :
citations: 13
Reference
Pérez Berezo T, Pujo J, Martin P, Le Faouder P, Galano J, Guy A, et al. Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917. Nat Commun. 2017;8:1314 pubmed publisher
Diepenbruck M, Tiede S, Saxena M, Ivanek R, Kalathur R, Lüönd F, et al. miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis. Nat Commun. 2017;8:1168 pubmed publisher
Harte Hargrove L, Varga Wesson A, Duffy A, Milner T, Scharfman H. Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat. J Neurosci. 2015;35:1723-38 pubmed publisher
Atasoy D, Betley J, Li W, Su H, Sertel S, Scheffer L, et al. A genetically specified connectomics approach applied to long-range feeding regulatory circuits. Nat Neurosci. 2014;17:1830-9 pubmed publisher
Atasoy D, Betley J, Su H, Sternson S. Deconstruction of a neural circuit for hunger. Nature. 2012;488:172-7 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Kramar E, Chen L, Brandon N, Rex C, Liu F, Gall C, et al. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 2009;29:12982-93 pubmed publisher
Miyazato M, Sasatomi K, Hiragata S, Sugaya K, Chancellor M, de Groat W, et al. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. J Urol. 2008;179:1178-83 pubmed publisher
Ying S, Goldstein P. Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. Mol Pain. 2005;1:2 pubmed
Ohba S, Ikeda T, Ikegaya Y, Nishiyama N, Matsuki N, Yamada M. BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Cereb Cortex. 2005;15:291-8 pubmed
Melyan Z, Lancaster B, Wheal H. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci. 2004;24:4530-4 pubmed
Piet R, Vargova L, Sykova E, Poulain D, Oliet S. Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Proc Natl Acad Sci U S A. 2004;101:2151-5 pubmed
Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed
image
image 1 :
Tocris Bioscience 0246/10 image 1
Cat.No. 0246 - Saclofen C9H12ClNO3S CAS No. 125464-42-8
product information
master code :
246
SKU :
0246/10
product name :
Saclofen
unit size :
10 mg (also 50 mg)
description :
Selective GABAB antagonist
target :
GABA-B Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
249.72
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Saclofen is a selective antagonist at GABAB receptors.
top caption :
Selective GABAB antagonist
extended description :
Selective GABAB antagonist
chemical name text :
(RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
formula :
C9H12ClNO3S
formula text :
C9H12ClNO3S
cas num :
125464-42-8
USD :
271 USD
product details :
Selective GABAB antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK