product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0237/10
catalog :
0237/10
quantity :
10 mg (also 50 mg)
price :
109 USD
more info or order :
citations: 7
Reference
Meunier C, Wang N, Yi C, Dallérac G, Ezan P, Koulakoff A, et al. Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex. J Neurosci. 2017;37:9064-9075 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
De Biase L, Kang S, Baxi E, Fukaya M, Pucak M, Mishina M, et al. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Neurosci. 2011;31:12650-62 pubmed publisher
Baltan S, Besancon E, Mbow B, Ye Z, Hamner M, Ransom B. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J Neurosci. 2008;28:1479-89 pubmed publisher
Vigot R, Barbieri S, Brauner Osborne H, Turecek R, Shigemoto R, Zhang Y, et al. Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 2006;50:589-601 pubmed
Shin H, Dunn A, Jones P, Boas D, Moskowitz M, Ayata C. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab. 2006;26:1018-30 pubmed
Casado M, Dieudonne S, Ascher P. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Proc Natl Acad Sci U S A. 2000;97:11593-7 pubmed
product information
master code :
237
SKU :
0237/10
product name :
7-Chlorokynurenic acid
unit size :
10 mg (also 50 mg)
description :
Potent competitive inhibitor of L-glutamate uptake
target :
Glutamate (EAAT) Transporter Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
223.62
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
7-Chlorokynurenic acid is an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. . Sodium Salt also available.
top caption :
Potent competitive inhibitor of L-glutamate uptake
extended description :
Potent competitive inhibitor of L-glutamate uptake
chemical name text :
7-Chloro-4-hydroxyquinoline-2-carboxylic acid
formula :
C10H6ClNO3
formula text :
C10H6ClNO3
cas num :
18000-24-3
USD :
109 USD
product details :
Potent competitive inhibitor of L-glutamate uptake
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK