product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Isoguvacine hydrochloride
catalog :
0235
quantity :
100 mg
price :
223 USD
more info or order :
citations: 5
Reference
Edwards N, Anderson C, Gatfield K, Jevons M, Ganapathy V, Thwaites D. Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta. 2011;1808:260-70 pubmed publisher
Lobb C, Wilson C, Paladini C. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol. 2010;104:403-13 pubmed publisher
Sipilä S, Huttu K, Yamada J, Afzalov R, Voipio J, Blaesse P, et al. Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci. 2009;29:6982-8 pubmed publisher
Long P, Mercer A, Begum R, Stephens G, Sihra T, Jovanovic J. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. J Biol Chem. 2009;284:8726-37 pubmed publisher
Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed
product information
brand :
Tocris
master code :
0235
SKU :
0235/100
product name :
Isoguvacine hydrochloride
description :
Selective GABAA agonist
target :
GABA-A Receptor Agonists
category :
Small Molecules
unit size :
100 mg
purity :
99%
observed molecular weight :
163.6
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.
catalog number base :
235
product keywords :
Selective GABAA agonists Receptors GABAA Receptors 0235,
extended description :
Selective GABAA agonist
chemical name text :
1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
formula :
C 6 H 9 NO 2 .HCl
formula text :
C6H9NO2.HCl
cas num :
68547-97-7
2020 USD :
216
2021 USD :
223 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK