product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0235/100
catalog :
0235/100
quantity :
100 mg
price :
281 USD
more info or order :
citations: 6
Reference
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Edwards N, Anderson C, Gatfield K, Jevons M, Ganapathy V, Thwaites D. Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta. 2011;1808:260-70 pubmed publisher
Lobb C, Wilson C, Paladini C. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol. 2010;104:403-13 pubmed publisher
Sipilä S, Huttu K, Yamada J, Afzalov R, Voipio J, Blaesse P, et al. Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci. 2009;29:6982-8 pubmed publisher
Long P, Mercer A, Begum R, Stephens G, Sihra T, Jovanovic J. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. J Biol Chem. 2009;284:8726-37 pubmed publisher
Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed
product information
master code :
235
SKU :
0235/100
product name :
Isoguvacine hydrochloride
unit size :
100 mg
description :
Selective GABAA agonist
target :
GABA-A Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
163.6
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Isoguvacine hydrochloride is a specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.
top caption :
Selective GABAA agonist
extended description :
Selective GABAA agonist
chemical name text :
1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
formula :
C6H9NO2.HCl
formula text :
C6H9NO2.HCl
cas num :
68547-97-7
USD :
281 USD
product details :
Selective GABAA agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK